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Artículo

Assessment of trade-offs between simultaneous immune challenges in a slow-living subterranean rodent

Merlo, JulietaIcon ; Cutrera, Ana PaulaIcon ; Zenuto, Roxana RitaIcon
Fecha de publicación: 01/2019
Editorial: University of Chicago Press
Revista: Physiological and Biochemical Zoology
ISSN: 1522-2152
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología

Resumen

The coexistence of two or more infectious agents in the same host is common in nature. Given this, the study of trade-offs within the immune system itself is key to understanding how immune defenses act in wild species in their natural environment. Here we assessed the possible trade-off between an inflammatory response (induced by phytohemagglutinin [PHA]; involving innate and adaptive responses in the study species) and an antibody response (induced by sheep red blood cells [SRBC]; adaptive response) in a slow-living subterranean rodent, the Talas tuco-tuco (Ctenomys talarum Thomas, 1898). According to life-history theory, slow-living species should rely more heavily on adaptive immunity, which develops more slowly than an innate response but is beneficial against repeated infections. Individual physiological condition (estimated by measuring levels of infection and immune, nutritional, and stress parameters) was analyzed during immune challenges. Contrary to what was expected, we found that the magnitude and energetic costs of both immune responses were similar when stimulated alone or simultaneously. Variation in natural antibodies, neutrophils, basophils, total leukocytes, and the ratio of neutrophils to lymphocytes in relation to the different treatments was also detected. In particular, natural antibodies were negatively affected by the induction of both immune challenges simultaneously and an increase of neutrophil counts was detected in all animals with the exception of those challenged with SRBC, while the pattern of variation of basophils, total leukocytes, and ratio of neutrophils to lymphocytes was not clearly associated with any triggered immune response. In general, our results suggest the absence of an energetic or resource-based trade-off between the immune responses triggered by PHA and SRBC in C. talarum.
Palabras clave: HUMORAL RESPONSE , INFLAMMATION , LIFE HISTORY , TALAS TUCO-TUCOS
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/126375
URL: https://www.journals.uchicago.edu/doi/10.1086/701320
DOI: https://doi.org/10.1086/701320
Colecciones
Articulos(IIMYC)
Articulos de INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
Merlo, Julieta; Cutrera, Ana Paula; Zenuto, Roxana Rita; Assessment of trade-offs between simultaneous immune challenges in a slow-living subterranean rodent; University of Chicago Press; Physiological and Biochemical Zoology; 92; 1; 1-2019; 92-105
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