Mostrar el registro sencillo del ítem
dc.contributor.author
Hollander, Jessica
dc.contributor.author
McNivens, Megan
dc.contributor.author
Pautassi, Ricardo Marcos
dc.contributor.author
Nizhnikov, Michael
dc.date.available
2021-02-23T20:05:13Z
dc.date.issued
2019-05
dc.identifier.citation
Hollander, Jessica; McNivens, Megan; Pautassi, Ricardo Marcos; Nizhnikov, Michael; Offspring of male rats exposed to binge alcohol exhibit heightened ethanol intake at infancy and alterations in T-maze performance; Elsevier Science Inc; Alcohol; 76; 5-2019; 65-71
dc.identifier.issn
0741-8329
dc.identifier.uri
http://hdl.handle.net/11336/126373
dc.description.abstract
Alcohol use is associated with a variety of negative consequences, including heightened likelihood of cognitive impairment, proclivity to alcohol use disorders (AUD), and alterations in the drinker's offspring. Children and rodents exposed to alcohol during pregnancy, or those whose fathers consumed alcohol prior to mating, often exhibit neurodevelopmental, physiological, and behavioral deficits. The present study assessed cognitive function and alcohol intake in male and female rats that were offspring of alcohol-exposed fathers. Adult male rats were exposed to alcohol or vehicle (0.0 or 2.0 g/kg, respectively; twice daily for 2 days followed by a rest day, for a total of eight alcohol or vehicle exposure days), or were left untreated and then mated with non-manipulated females. The offspring were assessed for alcohol intake, via intraoral infusion, followed by cognitive assessment via an alternating T-maze task. The results indicated that paternal ethanol exposure, prior to breeding, resulted in offspring that consumed significantly more ethanol than vehicle or untreated controls. Furthermore, the offspring of alcohol-exposed fathers exhibited a significant failure to initiate and complete the T-maze performance tests. Although, when they did engage in the tests they performed at the level of controls (i.e., 80% correct). The present results add to a growing body of literature suggesting that paternal pre-conception alcohol exposure can have deleterious effects on the offspring.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALCOHOL INTAKE
dc.subject
PATERNAL ALCOHOL EXPOSURE
dc.subject
PREGNANCY
dc.subject
T-MAZE
dc.subject.classification
Drogadicción
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Offspring of male rats exposed to binge alcohol exhibit heightened ethanol intake at infancy and alterations in T-maze performance
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:20:42Z
dc.journal.volume
76
dc.journal.pagination
65-71
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Hollander, Jessica. Southern Connecticut State University; Estados Unidos
dc.description.fil
Fil: McNivens, Megan. Southern Connecticut State University; Estados Unidos
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Nizhnikov, Michael. Southern Connecticut State University; Estados Unidos
dc.journal.title
Alcohol
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0741832918300739
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.alcohol.2018.07.013
Archivos asociados