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dc.contributor.author
Chang, Daniel Victor  
dc.contributor.author
Teper, Alejandro Manuel  
dc.contributor.author
Balinotti, Juan Emilio  
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Castro Simonelli, Christian  
dc.contributor.author
Garcia Bournissen, Facundo  
dc.contributor.author
Kofman, Carlos  
dc.date.available
2021-02-22T15:48:28Z  
dc.date.issued
2019-05-27  
dc.identifier.citation
Chang, Daniel Victor; Teper, Alejandro Manuel; Balinotti, Juan Emilio; Castro Simonelli, Christian; Garcia Bournissen, Facundo; et al.; Exhaled nitric oxide predicts loss of asthma control in children after inhaled corticosteroids withdrawal; Veterinary and Human Toxicology; Pediatric Pulmonology; 54; 5; 27-5-2019; 537-543  
dc.identifier.issn
8755-6863  
dc.identifier.uri
http://hdl.handle.net/11336/126235  
dc.description.abstract
Background: Exhaled nitric oxide (eNO) has been proposed for monitoring airway inflammation, diagnosis, and prediction of steroid responsiveness in asthma. However, its utility after elective suspension of asthma medication is still unclear. We aimed to determine the association between eNO values and the subsequent loss of asthma control (LAC) in asymptomatic asthmatic children after inhaled corticosteroids (ICS) withdrawal. Methods: We conducted a prospective observational cohort study. Forty-two children (23 boys), mean age 11 years, with clinically controlled asthma, according to GINA guidelines, and receiving low-dose of ICS (budesonide 200 μg/day or equivalent) were included immediately after the withdrawal of ICS. eNO, Asthma Control Test (ACT) and spirometry were monthly assessed, during 54 weeks or until the presence of at least one of the following criteria of LAC: 1) asthma exacerbation, 2) obstructive spirometric pattern, 3) ACT ≤ 19. Results: eNO baseline geometric mean (eNO b ), measured 4 weeks after discontinuation of ICS, was 23.7 ppb (SD: 1.16). An eNO b cutoff point of 21.8 ppb was determined to better discriminate between high and low eNO groups. Twenty-five subjects (71.4%) had LAC. High eNO b was associated to LAC (OR: 9.01; 95CI: 1.10-74.26). In addition, LAC occurred earlier in high eNO b than in low eNO b patients (8 vs 28 weeks, respectively; P = 0.017). Conclusions: Our findings suggest that eNO predicts loss of asthma control and may contribute for clinical follow up decisions during childhood asthma after ICS withdrawal.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Veterinary and Human Toxicology  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ASTHMA  
dc.subject
EXHALED NITRIC OXIDE  
dc.subject
INHALED CORTICOSTEROIDS  
dc.subject.classification
Pediatría  
dc.subject.classification
Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Exhaled nitric oxide predicts loss of asthma control in children after inhaled corticosteroids withdrawal  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-19T21:37:56Z  
dc.journal.volume
54  
dc.journal.number
5  
dc.journal.pagination
537-543  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Chang, Daniel Victor. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina  
dc.description.fil
Fil: Teper, Alejandro Manuel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina  
dc.description.fil
Fil: Balinotti, Juan Emilio. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Castro Simonelli, Christian. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina  
dc.description.fil
Fil: Garcia Bournissen, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Kofman, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina  
dc.journal.title
Pediatric Pulmonology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ppul.24268  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24268