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dc.contributor.author
Clancy, Colleen E.
dc.contributor.author
Chen Izu, Ye
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Bers, Donald M.
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Belardinelli, Luiz
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Boyden, Penelope A.
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Csernoch, Laszlo
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Despa, Sanda
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Fermini, Bernard
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Hool, Livia C.
dc.contributor.author
Izu, Leighton
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Kaas, Robert S.
dc.contributor.author
Lederer, W. Jonathan
dc.contributor.author
Louch, William E.
dc.contributor.author
Maack, Christoph
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Mattiazzi, Ramona Alicia
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Qu, Zhilin
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Rajamani, Sridharan
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Rippinger, Crystal M.
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Sejersted, Ole M.
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O’Rourke, Brian
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Weiss, James N.
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Varró, András
dc.contributor.author
Zaza, Antonio
dc.date.available
2017-02-06T21:32:11Z
dc.date.issued
2015-03-15
dc.identifier.citation
Clancy, Colleen E.; Chen Izu, Ye; Bers, Donald M.; Belardinelli, Luiz; Boyden, Penelope A.; et al.; Deranged sodium to sudden death; The Physiological Society; The Journal Of Physiology; 593; 6; 15-3-2015; 1331-1345
dc.identifier.uri
http://hdl.handle.net/11336/12586
dc.description.abstract
In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na+ channel structure, function and regulation, and Na+/Ca2+ exchange and Na+/K+ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na+ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na+ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na+-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na+ channels and Na+ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
The Physiological Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sodium
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Cardiac Disease
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Metabolism
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Arrhythmias
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Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Deranged sodium to sudden death
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-25T13:58:55Z
dc.identifier.eissn
1469-7793
dc.journal.volume
593
dc.journal.number
6
dc.journal.pagination
1331-1345
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Clancy, Colleen E.. University Of California At Davis; Estados Unidos
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Fil: Chen Izu, Ye. University Of California At Davis; Estados Unidos
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Fil: Bers, Donald M.. University Of California At Davis; Estados Unidos
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Fil: Belardinelli, Luiz. Gilead Sciences; Estados Unidos
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Fil: Boyden, Penelope A.. Columbia University; Estados Unidos
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Fil: Csernoch, Laszlo. University of Debrecen; Hungría
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Fil: Despa, Sanda. University Of Kentucky; Estados Unidos
dc.description.fil
Fil: Fermini, Bernard. Pfizer; Estados Unidos
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Fil: Hool, Livia C.. University of Western Australia; Australia
dc.description.fil
Fil: Izu, Leighton. University Of California At Davis; Estados Unidos
dc.description.fil
Fil: Kaas, Robert S.. Columbia University; Estados Unidos
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Fil: Lederer, W. Jonathan. University of Maryland; Estados Unidos
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Fil: Louch, William E.. University Of Oslo; Noruega
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Fil: Maack, Christoph. Universitat Saarland; Alemania
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Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
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Fil: Qu, Zhilin. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Rajamani, Sridharan. Gilead Sciences; Estados Unidos
dc.description.fil
Fil: Rippinger, Crystal M.. University Of California At Davis; Estados Unidos
dc.description.fil
Fil: Sejersted, Ole M.. University Of Oslo; Noruega
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Fil: O’Rourke, Brian. University Johns Hopkins; Estados Unidos
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Fil: Weiss, James N.. University of California at Los Angeles; Estados Unidos
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Fil: Varró, András. University of Szeged; Hungría
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Fil: Zaza, Antonio. Universita Degli Studi Di Milano; Italia
dc.journal.title
The Journal Of Physiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1113/jphysiol.2014.281204
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.281204/abstract
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