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dc.contributor.author
Gori, María Belén
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Pereyra, Magdalena
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Toibaro, Lucas
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Brescacin, Carola
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Battaglia, Gerardo Ángel
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Pastorino, Julieta
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Smigliani, Ariela
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Galardi, Milagros
dc.contributor.author
Kochen, Silvia
dc.date.available
2015-07-17T13:37:26Z
dc.date.issued
2013-06
dc.identifier.citation
Gori, María Belén; Pereyra, Magdalena; Toibaro, Lucas; Brescacin, Carola; Battaglia, Gerardo Ángel; et al.; Hippocampal high-frequency stimulation inhibites the progression of rapid kindling-induced seizure in rats; Academic Journals; Scientific Research And Essays; 2013; 4; 6-2013; 71-76
dc.identifier.issn
1992-2248
dc.identifier.uri
http://hdl.handle.net/11336/1257
dc.description.abstract
Epilepsy is one of the most common serious neurological disorders. Pharmacoresistant epilepsy patients are poorly con-trolled or their seizures are refractory to drug treatment. Resective surgery is frequently a promising therapy in this population, however, not all the patients meet the eligibility criteria for the surgical treatment. Deep brain stimulation has been investigated in clinical studies and animal studies as an alternative treatment, but the optimal stimulation pa- rameters remain an issue. The present study was designed to investigate the effect of unilateral high-frequency stimula- tion (HFS) of hippocampus on seizure development by using the hippocampal rapid kindling method (hRK) in rats, and compared the results with those of low-frequency stimulation previously published by our group. We used male Wistar rats implanted with electrodes in the ventral hippocampus. All rats underwent hRK (biphasic square wave pulses, 20 Hz for 10 seconds) during three consecutive days (twelve stimulations per day). The control group (hRK; n = 7) received only RK stimulus, while the treated group (HFS-hRK; n = 9) received also HFS (biphasic square wave pulses, 130 Hz for 30 seconds) immediately before the RK stimulus, during three consecutive days. At the end of behavioral testing 78% (p < 0.01) of the animals receiving HFS treatment were still not fully kindled staying in stages 0 - III (p < 0.01). HFS group needed a higher number of stimulations to achieve stage III (p < 0.05) with respect to control group. How- ever, no significant differences in the cumulative daily afterdischarge duration were observed. HFS did not present sig- nificant differences compared with LFS in any of studied parameters. The findings suggest that unilateral HFS applied on hippocampus effectively inhibited the epileptogenic process induced by hippocampal rapid kindling. According to the comparative results about hippocampal rapid kindled animals stimulated with HFS and LFS (5 Hz), we found no conclusive information on which treatment is most efficient.
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application/pdf
dc.language.iso
eng
dc.publisher
Academic Journals
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HIPPOCAMPAL RAPID KINDLING
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EPILEPSY
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ELECTRICAL STIMULATION
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HIGH-FREQUENCY STIMULATION
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LOW-FREQUENCY STIMULATION
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Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Hippocampal high-frequency stimulation inhibites the progression of rapid kindling-induced seizure in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
2013
dc.journal.number
4
dc.journal.pagination
71-76
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Gori, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Pereyra, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
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Fil: Toibaro, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
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Fil: Brescacin, Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
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Fil: Battaglia, Gerardo Ángel. Universidad Tecnológica Nacional; Argentina
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Fil: Pastorino, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Smigliani, Ariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Galardi, Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
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Fil: Kochen, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.journal.title
Scientific Research And Essays
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/nm.2013.42011
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info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/nm