Artículo
Room-temperature and transition-metal-free intramolecular α-arylation of ketones: A mild access to tetracyclic indoles and 7-azaindoles
Adouama, Chérif; Buden, Maria Eugenia
; Guerra, Walter Damián
; Puiatti, Marcelo
; Joseph, Benoît; Barolo, Silvia Maricel
; Rossi, Roberto Arturo
; Médebielle, Maurice
Fecha de publicación:
01/2019
Editorial:
American Chemical Society
Revista:
Organic Letters
ISSN:
1523-7060
e-ISSN:
1523-7052
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A novel approach for the synthesis of tetracyclic indoles and 7-azaindoles is reported. The strategy involves four steps, with a fast rt intramolecular α-arylation of ketones as key step. The reaction was inspected synthetically to achieve the synthesis of 11 novel tetracyclic structures with moderate to very good yields (39-85%). Theoretical combined with experimental studies led us to propose a probable polar mechanism (concerted S N Ar).
Palabras clave:
HETEROCYCLE
,
SYNTHESIS
,
AROMATIC NUCLEOPHILIC SUBSTITUTION
,
DFT
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Adouama, Chérif; Buden, Maria Eugenia; Guerra, Walter Damián; Puiatti, Marcelo; Joseph, Benoît; et al.; Room-temperature and transition-metal-free intramolecular α-arylation of ketones: A mild access to tetracyclic indoles and 7-azaindoles; American Chemical Society; Organic Letters; 21; 1; 1-2019; 320-324
Compartir
Altmétricas