Artículo
Assay based on electrical impedance spectroscopy to discriminate between normal and cancerous mammalian cells
Fecha de publicación:
19/03/2018
Editorial:
American Physical Society
Revista:
Physical Review E: Statistical, Nonlinear and Soft Matter Physics
ISSN:
1539-3755
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In this work we present an assay to discriminate between normal and cancerous cells. The method is based on the measurement of electrical impedance spectra of in vitro cell cultures. We developed a protocol consisting on four consecutive measurement phases, each of them designed to obtain different information about the cell cultures. Through the analysis of the measured data, 26 characteristic features were obtained for both cell types. From the complete set of features, we selected the most relevant in terms of their discriminant capacity by means of conventional statistical tests. A linear discriminant analysis was then carried out on the selected features, allowing the classification of the samples in normal or cancerous with 4.5% of false positives and no false negatives.
Palabras clave:
DISCRIMINATE
,
CELL
,
IMPEDANCE
,
STATISTICAL TESTS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - PATAGONIA NORTE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - PATAGONIA NORTE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - PATAGONIA NORTE
Citación
Giana, Fabián Eduardo; Bonetto, Fabian Jose; Bellotti, Mariela; Assay based on electrical impedance spectroscopy to discriminate between normal and cancerous mammalian cells; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 97; 3; 19-3-2018; 1-10
Compartir
Altmétricas