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dc.contributor.author
Netti, Vanina Alejandra
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Vatrella, Mariana C.
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Chamorro, Melina Fernanda
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Roson, Melina F.
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Zotta, Elsa
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Fellet, Andrea L
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Balaszczuk, Ana M.
dc.date.available
2017-02-06T20:44:27Z
dc.date.issued
2013-04
dc.identifier.citation
Netti, Vanina Alejandra; Vatrella, Mariana C.; Chamorro, Melina Fernanda; Roson, Melina F.; Zotta, Elsa; et al.; Comparison of cardiovascular aquaporin-1 changes during water restriction between 25- and 50-day-old rats; Springer; European Journal Of Nutrition; 53; 1; 4-2013; 287–295
dc.identifier.issn
1436-6207
dc.identifier.uri
http://hdl.handle.net/11336/12550
dc.description.abstract
Purpose Aquaporin-1 (AQP1) is the predominant water channel in the heart, linked to cardiovascular homeostasis. Our aim was to study cardiovascular AQP1 distribution and protein levels during osmotic stress and subsequent hydration during postnatal growth. Methods Rats aged 25 and 50 days were divided in: 3d-WR: water restriction 3 days; 3d-WAL: water ad libitum 3 days; 6d-WR+ORS: water restriction 3 days + oral rehydration solution (ORS) 3 days; and 6d-WAL: water ad libitum 6 days. AQP1 was evaluated by immunohistochemistry and western blot in left ventricle, right atrium and thoracic aorta. Results Water restriction induced a hypohydration state in both age groups (40 and 25 % loss of body weight in 25- and 50-day-old rats, respectively), reversible with ORS therapy. Cardiac AQP1 was localized in the endocardium and endothelium in both age groups, being evident in cardiomyocytes membrane only in 50-day-old 3d-WR group, which presented increased protein levels of AQP1; no changes were observed in the ventricle of pups. In vascular tissue, AQP1 was present in the smooth muscle of pups; in the oldest group, it was found in the endothelium, increasing after rehydration in smooth muscle. No differences were observed between control groups 3d-WAL and 6d-WAL of both ages. Conclusion Our findings suggest that cardiovascular AQP1 can be differentially regulated in response to hydration status in vivo, being this response dependent on postnatal growth. The lack of adaptive mechanisms of mature animals in young pups may indicate an important role of this water channel in maintaining fluid balance during hypovolemic state.
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application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acuaporina 1
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Restriccion de Agua
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Aorta
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Corazon
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Comparison of cardiovascular aquaporin-1 changes during water restriction between 25- and 50-day-old rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T17:22:11Z
dc.journal.volume
53
dc.journal.number
1
dc.journal.pagination
287–295
dc.journal.pais
Alemania
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Berlín
dc.description.fil
Fil: Netti, Vanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Vatrella, Mariana C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Chamorro, Melina Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Roson, Melina F.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina
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Fil: Zotta, Elsa. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina
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Fil: Fellet, Andrea L. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Balaszczuk, Ana M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
European Journal Of Nutrition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00394-013-0527-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00394-013-0527-5