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dc.contributor.author
Ramos Casals, Manuel  
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Retamozo, Maria Soledad  
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Siso Almirall, Antoni  
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Pérez Alvarez, Roberto  
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Pallarés, Lucio  
dc.contributor.author
Brito Zenón, Pilar  
dc.date.available
2021-02-11T16:19:51Z  
dc.date.issued
2019-04  
dc.identifier.citation
Ramos Casals, Manuel; Retamozo, Maria Soledad; Siso Almirall, Antoni; Pérez Alvarez, Roberto; Pallarés, Lucio; et al.; Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis; Taylor & Francis; Expert Review Of Clinical Immunology; 15; 4; 4-2019; 391-405  
dc.identifier.issn
1744-666X  
dc.identifier.uri
http://hdl.handle.net/11336/125487  
dc.description.abstract
Introduction: Sarcoidosis is a complex systemic disease with a silent, long-term evolution, and a heterogeneous clinical presentation. The diagnostic approach is complex with no single diagnostic test that may confirm the disease. Areas covered: A large list of serum biomarkers has been tested during the last 40 years. In this review, we analyse the potential usefulness in the diagnosis and prognosis of sarcoidosis of serum biomarkers classified according to their corresponding cellular source. Expert commentary: Diagnosis of sarcoidosis must always be approached as a multistep process based on a case-by-case integration of clinical, radiological, histological and serological data, none of which being pathognomonic. We found sIL-2R, CRP, SAA and chitotriosidase to be the best markers to confirm sarcoidosis (highest sensitivity), while ACE, gammaglobulins and lysozyme may be more useful for discarding sarcoidosis (highest specificity), taking into account that with the use of a higher cut-off we can increase specificity and with a lower cut-off we can increase sensitivity. Other biomarkers (TNF-a and CCL18) could help to identify patients with an enhanced risk of developing pulmonary fibrosis or progressive disease. The future scenario of the serological diagnostic approach of sarcoidosis will be the use of multi-assays including biomarkers from different cellular sources.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANGIOTENSIN CONVERTASE ENZYME  
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B-CELLS  
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BIOMARKERS  
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CHITOTRIOSIDASE  
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CYTOKINES  
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MACROPHAGES  
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SARCOIDOSIS  
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T-CELLS  
dc.subject.classification
Reumatología  
dc.subject.classification
Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-19T21:13:50Z  
dc.journal.volume
15  
dc.journal.number
4  
dc.journal.pagination
391-405  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Ramos Casals, Manuel. Sociedad Española de Medicina; España. Instituto Clínic de Medicina y Dermatología; España  
dc.description.fil
Fil: Retamozo, Maria Soledad. Instituto Clínic de Medicina y Dermatología; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Instituto Modelo de Cardiología Privado; Argentina  
dc.description.fil
Fil: Siso Almirall, Antoni. Instituto de Investigaciones Biomédicas August Pi i Sunyer; España  
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Fil: Pérez Alvarez, Roberto. Sociedad Española de Medicina; España  
dc.description.fil
Fil: Pallarés, Lucio. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; España  
dc.description.fil
Fil: Brito Zenón, Pilar. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; España  
dc.journal.title
Expert Review Of Clinical Immunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1568240  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/1744666X.2019.1568240