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dc.contributor.author
Martino, Renzo Fabricio
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dc.contributor.author
Sülsen, Valeria
dc.contributor.author
Alonso, Rosario
dc.contributor.author
Anesini, Claudia Alejandra
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dc.date.available
2017-02-06T18:53:08Z
dc.date.issued
2013-06
dc.identifier.citation
Martino, Renzo Fabricio; Sülsen, Valeria; Alonso, Rosario; Anesini, Claudia Alejandra; A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line; Elsevier; Leukemia Research; 37; 9; 6-2013; 1137-1143
dc.identifier.issn
0145-2126
dc.identifier.uri
http://hdl.handle.net/11336/12545
dc.description.abstract
Leukemia and lymphoma are a group of heterogeneous neoplastic disorder of white blood cells charac-terized by the uncontrolled proliferation and block in differentiation of hematopoietic cells. Nowadays,there is an interest in therapy with drugs of plant origin because conventional medicine can be inefficientor also results in side effects. Larrea divaricata Cav., is a plant widely distributed in Argentina that possessantiproliferative and antioxidant activities reported. Nordihydroguaiaretic acid (NDGA) was previouslyfound in the plant and related to both antiproliferative and pro-proliferative actions on a lymphoma cellline. In order to demonstrate whether the presence of NDGA may be beneficial or not in the antiprolifera-tive action of the aqueous extract, the extract of L. divaricata was submitted to a fractionation and fractionswith and without NDGA were studied in a murine lymphocitic leukemia cell line (EL-4) proliferation. Theeffect of the most active fraction was studied in relation to H2O2modulation and the synergistic actionbetween compounds, found in fractions, was analyzed. The presence of NDGA was not a detonator forpro-proliferative action and its presence could be beneficial in low concentrations allowing a synergistantiproliferative action with other compounds.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Larrea Divaricata
dc.subject
El4 Lymphoma
dc.subject
Ndga
dc.subject
Quercetin-3-Methyl Ether
dc.subject
Oxidative Stress
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T17:19:47Z
dc.journal.volume
37
dc.journal.number
9
dc.journal.pagination
1137-1143
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Martino, Renzo Fabricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Sülsen, Valeria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Alonso, Rosario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Anesini, Claudia Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
dc.journal.title
Leukemia Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.leukres.2013.06.004
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0145212613001902
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