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dc.contributor.author
Retamozo, Maria Soledad
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dc.contributor.author
Brito Zenon, P.
dc.contributor.author
Ramos Casals, M.
dc.date.available
2021-02-10T17:18:44Z
dc.date.issued
2019-07
dc.identifier.citation
Retamozo, Maria Soledad; Brito Zenon, P.; Ramos Casals, M.; Prognostic markers of lymphoma development in primary Sjögren syndrome; Sage Publications Ltd; Lupus; 28; 8; 7-2019; 923-936
dc.identifier.issn
0961-2033
dc.identifier.uri
http://hdl.handle.net/11336/125337
dc.description.abstract
Sjögren syndrome is a systemic autoimmune disease that principally affects women between the fourth and sixth decades of life who present with sicca symptomatology caused by dryness of the main mucosal surfaces. The clinical spectrum of Sjögren syndrome extends from dryness to systemic involvement. Since 1978, Sjögren syndrome has been closely associated with an enhanced risk of lymphoma, one of the most severe complications a patient may develop. Primary Sjögren syndrome patients have a 10–44-fold greater risk of lymphoma than healthy individuals, higher than that reported for systemic lupus erythematosus and rheumatoid arthritis. The close link between lymphoma and Sjögren syndrome is clearly exemplified by the very specific type of lymphoma arising in Sjögren syndrome patients, mainly low-grade B-cell lymphomas (predominantly a marginal zone histological type) with primary extranodal involvement of the major salivary glands (overwhelmingly parotid), with a primordial role of cryoglobulinemic-related markers (both clinical and immunological). The most recent studies support a higher number of risk factors detected in an individual leads to a higher lymphoma risk. A close follow-up of high-risk groups with longitudinal assessments of all known risk factors, including cryoglobulin-related markers and EULAR Sjögren's syndrome disease activity index measurement in particular, is mandatory.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sage Publications Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LYMPHOMA
dc.subject
PROGNOSTIC MARKERS
dc.subject
SJOGREN SYNDROME
dc.subject.classification
Reumatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.subject.classification
Oncología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Prognostic markers of lymphoma development in primary Sjögren syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:13:47Z
dc.journal.volume
28
dc.journal.number
8
dc.journal.pagination
923-936
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Retamozo, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.description.fil
Fil: Brito Zenon, P.. Instituto de Investigaciones Biomédicas August Pi i Sunyer; España
dc.description.fil
Fil: Ramos Casals, M.. Instituto de Investigaciones Biomédicas August Pi i Sunyer; España
dc.journal.title
Lupus
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/0961203319857132
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0961203319857132
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