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dc.contributor.author
León Félix, L.  
dc.contributor.author
Sanz, B.  
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Sebastián, V.  
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Torres Molina, Teobaldo Enrique  
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Sousa, Marcelo Henrique  
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Coaquira, J. A. H.  
dc.contributor.author
Ibarra, M.R.  
dc.contributor.author
Goya, Gerardo Fabian  
dc.date.available
2021-02-09T03:06:19Z  
dc.date.issued
2019-03-12  
dc.identifier.citation
León Félix, L.; Sanz, B.; Sebastián, V.; Torres Molina, Teobaldo Enrique; Sousa, Marcelo Henrique; et al.; Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization; Nature Publishing Group; Scientific Reports; 9; 1; 12-3-2019; 1-11  
dc.identifier.uri
http://hdl.handle.net/11336/125157  
dc.description.abstract
The integration of noble metal and magnetic nanoparticles with controlled structures that can couple various specific effects to the different nanocomposite in multifunctional nanosystems have been found interesting in the field of medicine. In this work, we show synthesis route to prepare small Au nanoparticles of sizes = 3.9 ± 0.2 nm attached to Fe 3 O 4 nanoparticle cores ( = 49.2 ± 3.5 nm) in aqueous medium for potential application as a nano-heater. Remarkably, the resulted Au decorated PEI-Fe 3 O 4 (Au@PEI-Fe 3 O 4 ) nanoparticles are able to retain bulk magnetic moment M S = 82–84 Am 2 /kg Fe3O4 , with the Verwey transition observed at T V = 98 K. In addition, the in vitro cytotoxicity analysis of the nanosystem microglial BV2 cells showed high viability (>97.5%) to concentrate up to 100 µg/mL in comparison to the control samples. In vitro heating experiments on microglial BV2 cells under an ac magnetic field (H 0 = 23.87 kA/m; f = 571 kHz) yielded specific power absorption (SPA) values of SPA = 43 ± 3 and 49 ± 1 μW/cell for PEI-Fe 3 O 4 and Au@PEI-Fe 3 O 4 NPs, respectively. These similar intracellular SPA values imply that functionalization of the magnetic particles with Au did not change the heating efficiency, providing at the same time a more flexible platform for multifunctional functionalization.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Nature Publishing Group  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
GOLD NANOPARTICLES  
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NANOMAGNETISM  
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HYPERTHERMIA  
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SURFACE FUNCTIONALIZATION  
dc.subject.classification
Física de los Materiales Condensados  
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Ciencias Físicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-12-16T18:23:25Z  
dc.identifier.eissn
2045-2322  
dc.journal.volume
9  
dc.journal.number
1  
dc.journal.pagination
1-11  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: León Félix, L.. Universidade do Brasília; Brasil. Universidad de Zaragoza; España  
dc.description.fil
Fil: Sanz, B.. Nb Nanoscale Biomagnetics S.l.; España  
dc.description.fil
Fil: Sebastián, V.. Universidad de Zaragoza; España. Centro de Investigación en Red en Bioingeniería; España  
dc.description.fil
Fil: Torres Molina, Teobaldo Enrique. Universidad de Zaragoza; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina  
dc.description.fil
Fil: Sousa, Marcelo Henrique. Universidade do Brasília; Brasil  
dc.description.fil
Fil: Coaquira, J. A. H.. Universidade do Brasília; Brasil  
dc.description.fil
Fil: Ibarra, M.R.. Universidad de Zaragoza; España  
dc.description.fil
Fil: Goya, Gerardo Fabian. Universidad de Zaragoza; España  
dc.journal.title
Scientific Reports  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-019-40769-2  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-019-40769-2