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dc.contributor.author
Bacigalupo, Maria Lorena
dc.contributor.author
Manzi, Malena
dc.contributor.author
Rabinovich, Gabriel Adrian
dc.contributor.author
Troncoso, María Fernanda
dc.date.available
2015-07-16T17:13:33Z
dc.date.issued
2013-12
dc.identifier.citation
Bacigalupo, Maria Lorena; Manzi, Malena; Rabinovich, Gabriel Adrian; Troncoso, María Fernanda; Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma; W J G Press; World Journal Of Gastroenterology; 19; 12-2013; 8831-8847
dc.identifier.issn
1007-9327
dc.identifier.uri
http://hdl.handle.net/11336/1249
dc.description.abstract
Hepatocellular carcinoma (HCC) represents a global health problem. Infections with hepatitis B or C virus, non-alcoholic steatohepatitis disease, alcohol abuse, or dietary exposure to aflatoxin are the major risk factors to the development of this tumor. Regardless of the carcinogenic insult, HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis. Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity for β-galactosides and conserved sequence motifs. Here, we summarize the current literature implicating galectins in the pathogenesis of HCC. Expression of ?proto-type? galectin-1, ?chimera- type? galectin-3 and ?tandem repeat-type? galectin- 4 is up-regulated in HCC cells compared to their normal counterparts. On the other hand, the ?tandemrepeat- type? lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes. The abnormal expression of these galectins correlates with tumor growth, HCC cell migration and invasion, tumor aggressiveness, metastasis, postoperative recurrence and poor prognosis. Moreover, these galectins have important roles in other pathological conditions of the liver, where chronic inflammation and/or fibrosis take place. Galectin-based therapies have been proposed to attenuate liver pathologies. Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
W J G Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-sa/2.5/ar/
dc.subject
Galectinas
dc.subject
Hepatocellular Carcinoma
dc.subject
Inflammation-Associated Liver Injury
dc.subject
Hepatitis B or C Virus Infection-Associated Hepatocellular Carcinoma
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Fibrosis-Related Liver Pathologies
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
2219-2840
dc.journal.volume
19
dc.journal.pagination
8831-8847
dc.journal.pais
China
dc.journal.ciudad
Beijing
dc.description.fil
Fil: Bacigalupo, Maria Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas . Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas; Argentina;
dc.description.fil
Fil: Manzi, Malena. Consejo Nacional de Investigaciones Científicas y Técnicas . Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas; Argentina;
dc.description.fil
Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biologia y Medicina Experimental (i); Argentina;
dc.description.fil
Fil: Troncoso, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas . Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas; Argentina;
dc.journal.title
World Journal Of Gastroenterology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.wjgnet.com/1007-9327/full/v19/i47/8831.htm


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  • Articulos(IBYME) [1166]
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