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dc.contributor.author
Sánchez Toranzo, G.
dc.contributor.author
Zapata Martínez, J.
dc.contributor.author
Catalan, Cesar Atilio Nazareno
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dc.contributor.author
Bühler, M. I.
dc.date.available
2017-02-03T20:02:28Z
dc.date.issued
2015-06
dc.identifier.citation
Sánchez Toranzo, G.; Zapata Martínez, J.; Catalan, Cesar Atilio Nazareno; Bühler, M. I.; Effect of different types of sesquiterpene lactones on the maturation of Rhinella Arenarum oocytes; Cambridge University Press; Zygote; 23; 3; 6-2015; 406-411
dc.identifier.issn
0967-1994
dc.identifier.uri
http://hdl.handle.net/11336/12486
dc.description.abstract
The sesquiterpene lactones (STLs) are a large class of plant secondary metabolites that are generally found in the Asteraceae family and that have high diversity with respect to chemical structure as well as biological activity. STLs have been classified into different groups, such as guaianolides, germacranolides, and melampolides etc., based on their carboxylic skeleton. In amphibians, fully grown ovarian oocytes are arrested at the beginning of meiosis I. Under the stimulus of progesterone, this meiotic arrest is released and meiosis progresses to metaphase II, a process known as oocyte maturation. The purpose of this work was to determine whether sesquiterpene lactones from the germacranolide and melampolide groups act as inhibitor agents on the meiosis of amphibian oocytes in vitro. Results for germacranolides indicated that the addition of deoxyelephantopins caused a high degree of inhibition and that minimolide showed a moderate inhibitory effect, whereas glaucolide A was inactive. Furthermore, the addition of melampolides (uvedalin, enhydrin, polymatin A and polymatin B) showed inhibitory effects. For enhydrin and uvedalin, inhibitory effects were observed at the higher concentrations assayed. The results of this study suggest that the inhibitory activity of the tested sesquiterpene lactones on the meiosis of Rhinella arenarum oocytes is not dependent on the group to which they belong, i.e. not on the carboxylic skeleton, but probably due to the arrangement and type of function groups present in the molecules. All assayed lactones in the germacranolide group showed low toxicity. In contrast, important differences in toxicity were observed for lactones from the melampolide group: enhydrin and uvedalin showed low toxicity, but polymatin A and B were highly toxic.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Amphibian
dc.subject
Meiosis
dc.subject
Oocyte Maturation
dc.subject
Sesquiterpene Lactone
dc.subject.classification
Biología Reproductiva
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Effect of different types of sesquiterpene lactones on the maturation of Rhinella Arenarum oocytes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-03T14:00:46Z
dc.identifier.eissn
1469-8730
dc.journal.volume
23
dc.journal.number
3
dc.journal.pagination
406-411
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Sánchez Toranzo, G.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Zapata Martínez, J.. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Biologia; Argentina
dc.description.fil
Fil: Catalan, Cesar Atilio Nazareno. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bühler, M. I.. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Biologia; Argentina
dc.journal.title
Zygote
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0967199413000695
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/zygote/article/div-classtitleeffect-of-different-types-of-sesquiterpene-lactones-on-the-maturation-of-span-classitalicrhinella-arenarumspan-oocytesdiv/900145B08B078FE6ACC537D7E932935C
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