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dc.contributor.author
Bongiovanni, Guillermina Azucena
dc.contributor.author
Perez, Roberto Daniel
dc.contributor.author
Mardirosian, Mariana Noelia
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Pérez, Carlos A.
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Marguí, Eva
dc.contributor.author
Queralt, Ignasi
dc.date.available
2021-02-01T15:48:10Z
dc.date.issued
2019-08
dc.identifier.citation
Bongiovanni, Guillermina Azucena; Perez, Roberto Daniel; Mardirosian, Mariana Noelia; Pérez, Carlos A.; Marguí, Eva; et al.; Comprehensive analysis of renal arsenic accumulation using images based on X-ray fluorescence at the tissue, cellular, and subcellular levels; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 150; 8-2019; 95-102
dc.identifier.issn
0969-8043
dc.identifier.uri
http://hdl.handle.net/11336/124373
dc.description.abstract
Exposure to arsenic (As)through drinking water results in accumulation of As and its methylated metabolites in several organs, promoting adverse health effects, particularly potential development of cancer. Arsenic toxicity is a serious global health concern since over 200 million people are chronically exposed worldwide. Abundant biochemical and epidemiological evidence indicates that the kidney is an important site of uptake and accumulation of As, and mitochondrial damage plays a crucial role in arsenic toxicity. However, non-destructive analyses and in situ images revealing As fate in renal cells and tissue are scarce or almost non-existent. In this work, kidney tissue from exposed rats was analyzed by EDXRF (Energy dispersive X-ray fluorescence), micro-SRXRF (micro X-ray Fluorescence using Synchrotron Radiation), SRTXRF (SRXRF in total reflection condition), SEM-EDX (Scanning Electron Microscope in combination with EDXRF)and SRXRF-XANES (SRXRF in combination with X-ray Absorption Near Edge Spectroscopy). Our results provide evidence of renal cortex distribution of As with periglomerular localization, co-localization of S, Cu and As in subcellular compartment of proximal tubule cells, mono-methylarsonous acid accumulation in renal cortex mitochondria, and altered subcellular concentration and distribution of other elements.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ARSENIC
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BIOACCUMULATION
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CHEMICAL MAPPING
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IMAGING
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MITOCHONDRIA
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NEPHROTOXICITY
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THIOARSENICALS
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XRF
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Geoquímica y Geofísica
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
dc.title
Comprehensive analysis of renal arsenic accumulation using images based on X-ray fluorescence at the tissue, cellular, and subcellular levels
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:26:50Z
dc.journal.volume
150
dc.journal.pagination
95-102
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Massachusetts
dc.description.fil
Fil: Bongiovanni, Guillermina Azucena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias; Argentina
dc.description.fil
Fil: Perez, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.description.fil
Fil: Mardirosian, Mariana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigaciones en Toxicología Ambiental y Agrobiotecnología del Comahue. Universidad Nacional del Comahue. Facultad de Ciencias Agrarias. Centro de Investigaciones en Toxicología Ambiental y Agrobiotecnología del Comahue; Argentina
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Fil: Pérez, Carlos A.. Ministério da Ciência, Tecnologia e Inovações. Centro Nacional de Pesquisa em Energia e Materiais; Brasil
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Fil: Marguí, Eva. Universidad de Girona; España
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Fil: Queralt, Ignasi. Consejo Superior de Investigaciones Científicas. Instituto de Diagnóstico Ambiental y Estudios del Agua; España
dc.journal.title
Applied Radiation and Isotopes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.apradiso.2019.05.018
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804319300685
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