Artículo
Effects of hypothyroidism on the mesenteric and omental adipose tissue in rats
López Fontana, Constanza Matilde
; Pennacchio, Gisela Erika
; Zyla, Leila Ester
; Toneatto, Judith
; Bruna, Flavia Alejandra
; Ortiz, Nicolás
; Sassi, Paola Lorena
; Santiano, Flavia Eliana
; García, S.; Sasso, Corina Verónica
; Pietrobon, Elisa Olivia
; Jahn, Graciela Alma
; Pistone Creydt, Virginia
; Soaje, Marta
; Carón, Rubén Walter
Fecha de publicación:
04/2019
Editorial:
Elsevier Ireland
Revista:
Molecular and Cellular Endocrinology
ISSN:
0303-7207
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
To characterize the influence of hypothyroidism on the endocrine activity of mesenteric and omental adipose tissue (MOAT) and the peripheral regulation of energy balance (EB) in rats, we analyzed food intake (FI); basal metabolic rate (BMR); locomotor activity; body weight (BW); serum hormone concentrations and the expression of their receptors in MOAT. Also, we evaluated the morphology and differentiation of adipocytes. Hypothyroidism decreased FI, BMR, BW and body length. The percentage of WAT depots and the morphology of adipocytes were similar to euthyroid rats. Leptin and adiponectin expressions in MOAT were altered by hypothyroidism. The expression of Perilipin A1, HSL, UCP1 and PRDM16 was significantly lower in MOAT of hypothyroid animals. Hypothyroidism in rats leads to a compensated EB by inducing a white adipocyte dysfunction and a decrease in BW, BMR, FI and adipokine secretions without changing the percentage of WAT depots and the morphology of the MOAT.
Palabras clave:
ADIPOKINES
,
ADIPOSE TISSUE
,
ENERGY BALANCE
,
HORMONAL PATTERNS
,
HYPOTHYROIDISM
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Identificadores
Colecciones
Articulos(IADIZA)
Articulos de INST. ARG DE INVEST. DE LAS ZONAS ARIDAS
Articulos de INST. ARG DE INVEST. DE LAS ZONAS ARIDAS
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
López Fontana, Constanza Matilde; Pennacchio, Gisela Erika; Zyla, Leila Ester; Toneatto, Judith; Bruna, Flavia Alejandra; et al.; Effects of hypothyroidism on the mesenteric and omental adipose tissue in rats; Elsevier Ireland; Molecular and Cellular Endocrinology; 490; 4-2019; 88-99
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Datos de investigación Efectos del hipotiroidismo sobre el tejido adiposo abdominal