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dc.contributor.author
Rodriguez, Matias Exequiel
dc.contributor.author
Arévalo, Daniela Elisa
dc.contributor.author
Milla Sanabria, Laura Natalia
dc.contributor.author
Cuello Carrión, Fernando Darío
dc.contributor.author
Fanelli, Mariel Andrea
dc.contributor.author
Rivarola, Viviana Alicia
dc.date.available
2021-01-29T17:18:53Z
dc.date.issued
2019-02
dc.identifier.citation
Rodriguez, Matias Exequiel; Arévalo, Daniela Elisa; Milla Sanabria, Laura Natalia; Cuello Carrión, Fernando Darío; Fanelli, Mariel Andrea; et al.; Heat shock protein 27 modulates autophagy and promotes cell survival after photodynamic therapy; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 18; 2; 2-2019; 546-554
dc.identifier.issn
1474-905X
dc.identifier.uri
http://hdl.handle.net/11336/124252
dc.description.abstract
Photodynamic therapy (PDT) is a clinically approved treatment that exerts a selective cytotoxic activity toward cancer cells. The procedure involves the administration of a photosensitizer drug followed by its activation by visible light. In the presence of oxygen, a series of events lead to tumor cell death. PDT releases different cell signals, some of these lead to death while others can lead to survival. The surviving or resistant cells contribute to the recurrence of tumors after treatment, from which the necessity to understand this molecular response induced by PDT arises. It has been shown that both Heat Shock Proteins (HSPs) and autophagy promote PDT resistance. Moreover, both of them can be stimulated by PDT treatment. However, the molecular interplay between HSPs and autophagy in the photodynamic therapy context is poorly understood. We studied whether PDT induces autophagic activity through HSPs. We demonstrated that PDT promoted HSP27 expression, which in turn triggered autophagic cell survival as well as inhibited apoptosis in colon cancer cells. In addition, an overexpression of the HSP27/autophagy axis was observed in skin carcinoma cells resistant to PDT.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PHOTODYNAMIC THERAPY
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HEAT SHOCK PROTEIN 27
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AUTOPHAGIC ACTIVITY
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SKIN CARCINOMA CELLS
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Heat shock protein 27 modulates autophagy and promotes cell survival after photodynamic therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T16:43:52Z
dc.journal.volume
18
dc.journal.number
2
dc.journal.pagination
546-554
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Rodriguez, Matias Exequiel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.description.fil
Fil: Arévalo, Daniela Elisa. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
dc.description.fil
Fil: Milla Sanabria, Laura Natalia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
dc.description.fil
Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Rivarola, Viviana Alicia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
dc.journal.title
Photochemical and Photobiological Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c8pp00536b
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2019/PP/C8PP00536B
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