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dc.contributor.author
Abraham Miranda, Julieta
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Garnero, Claudia
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Chattah, Ana Karina
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Santiago De Oliveira, Yara
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Ayala, Alejandro Pedro
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Longhi, Marcela Raquel
dc.date.available
2021-01-28T20:59:28Z
dc.date.issued
2019-04
dc.identifier.citation
Abraham Miranda, Julieta; Garnero, Claudia; Chattah, Ana Karina; Santiago De Oliveira, Yara; Ayala, Alejandro Pedro; et al.; Furosemide:Triethanolamine Salt as a Strategy to Improve the Biopharmaceutical Properties and Photostability of the Drug; American Chemical Society; Crystal Growth & Design; 19; 4; 4-2019; 2060-2068
dc.identifier.issn
1528-7483
dc.identifier.uri
http://hdl.handle.net/11336/124085
dc.description.abstract
With the purpose of enhancing the biopharmaceutical properties of the furosemide, a pharmaceutical salt was obtained and characterized by combining the drug and triethanolamine. The solid system was prepared using different techniques such as kneading, grinding, and slow evaporation. It was characterizated by X-ray powder diffraction, solid-state nuclear magnetic resonance, infrared and Raman spectroscopy, thermal analysis, and scanning electron microscopy. The results showed that the same pharmaceutical compound in solid state was obtained through the different preparation techniques. The crystalline structure was fully elucidated by single-crystal X-ray diffraction. The salt formation was confirmed by two-dimensional nuclear magnetic resonance experiments, which revealed the transference of the OH proton of the drug to triethanolamine. Besides, the solubility studies demonstrated an increase in the drug solubility attributed not only to a pH change but also to a soluble salt formation in solution. In addition, the combination of the drug with triethanolamine produces an enhancement of the chemical photostability, whereas the physical photostability and the hygroscopicity status were not modified. Finally, this new solid form of furosemide constitutes an interesting strategy to improve the biopharmaceutical properties and stability of furosemide, with potential application in pharmaceutical formulations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FUROSEMIDE
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TRIETHANOLAMINE
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CHARACTERIZATION
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SOLUBILITY
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STABILITY
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Furosemide:Triethanolamine Salt as a Strategy to Improve the Biopharmaceutical Properties and Photostability of the Drug
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:37:30Z
dc.journal.volume
19
dc.journal.number
4
dc.journal.pagination
2060-2068
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Abraham Miranda, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
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Fil: Santiago De Oliveira, Yara. Universidade Federal Do Ceara; Brasil
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Fil: Ayala, Alejandro Pedro. Universidade Federal Do Ceara; Brasil
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.journal.title
Crystal Growth & Design
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.cgd.8b01556
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.cgd.8b01556
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