Artículo
Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System
Rodríguez, Ana M.; Delpino, María Victoria
; Miraglia, Maria Cruz
; Giambartolomei, Guillermo Hernan
Fecha de publicación:
05/2019
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Neuroscience
ISSN:
0306-4522
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.
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Articulos (IVIT)
Articulos de INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Articulos de INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Rodríguez, Ana M.; Delpino, María Victoria; Miraglia, Maria Cruz; Giambartolomei, Guillermo Hernan; Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System; Pergamon-Elsevier Science Ltd; Neuroscience; 410; 5-2019; 264-273
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