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dc.contributor.author
Mignaqui, Ana Clara
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Ruiz, Vanesa
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Durocher, Yves
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Wigdorovitz, Andrés
dc.date.available
2021-01-26T17:33:05Z
dc.date.issued
2019-01
dc.identifier.citation
Mignaqui, Ana Clara; Ruiz, Vanesa; Durocher, Yves; Wigdorovitz, Andrés; Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids; Taylor & Francis; Critical Reviews In Biotechnology; 39; 3; 1-2019; 306-320
dc.identifier.issn
0738-8551
dc.identifier.uri
http://hdl.handle.net/11336/123793
dc.description.abstract
Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). Although inactivated virus vaccines have proved to be effective in FMD control, they have a number of disadvantages, including the need for high bio-containment production facilities and the lack of induction of immunological memory. Novel FMD vaccines based on the use of recombinant empty capsids have shown promising results. These recombinant empty capsids are attractive candidates because they avoid the use of virus in the production facilities but conserve its complete repertoire of conformational epitopes. However, many of these recombinant empty capsids require time-consuming procedures that are difficult to scale up. Achieving production of a novel and efficient FMD vaccine requires not only immunogenic antigens, but also industrially relevant processes. This review intends to summarize and compare the different strategies already published for the production of FMDV recombinant empty capsids, focusing on large-scale production.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DNA VACCINES
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FOOT AND MOUTH DISEASE VIRUS
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LARGE-SCALE PRODUCTION
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NOVEL VACCINES
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RECOMBINANT EMPTY CAPSIDS
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VIRAL VECTOR VACCINES
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VIRUS-LIKE PARTICLES
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-09T19:27:21Z
dc.journal.volume
39
dc.journal.number
3
dc.journal.pagination
306-320
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Mignaqui, Ana Clara. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Gastronómicas. Instituto de Virología E Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina
dc.description.fil
Fil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Gastronómicas. Instituto de Virología E Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina
dc.description.fil
Fil: Durocher, Yves. Human Health Therapeutics Research Center; Canadá
dc.description.fil
Fil: Wigdorovitz, Andrés. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Gastronómicas. Instituto de Virología E Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina
dc.journal.title
Critical Reviews In Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/07388551.2018.1554619
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/07388551.2018.1554619
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