Capítulo de Libro
Leptin and Gestational Diabetes Mellitus
Título del libro: Gestational Diabetes Mellitus: An Overview with Some Recent Advances
Guádix, Pilar; Pérez Pérez, Antonio; Vilariño, Teresa; Dueñas, Jose L.; Maymo, Julieta Lorena
; Varone, Cecilia Laura
; Sánchez Margalet, Victor
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Otros responsables:
Amita Ray
Fecha de publicación:
2019
Editorial:
IntechOpen
ISBN:
978-1-78985-187-8
Idioma:
Inglés
Clasificación temática:
Resumen
Emerging research has highlighted the importance of leptin in fetal growth anddevelopment, independent of its essential role in the regulation of feeding andenergy metabolism. Leptin is now considered an important signaling molecule ofthe reproductive system, since it regulates the production of gonadotropins, theblastocyst formation and implantation, the normal placentation, as well as the feto-placental communication. Placental leptin is an important cytokine which regulatesplacental functions in an autocrine or paracrine manner. Leptin seems to play acrucial role during the first stages of pregnancy as it modulates critical processes likeproliferation, protein synthesis, invasion, and apoptosis in placental cells. Further-more, deregulation of leptin levels has been correlated with the pathogenesis ofvarious disorders associated with reproduction and gestation, including gestationaldiabetes mellitus (GDM). Due to the relevant incidence of the GDM and theimportance of leptin, we decided to review the latest information available aboutleptin action in normal and GDM pregnancies to support the idea of leptin as animportant factor and/or predictor of diverse disorders associated with reproductionand pregnancy.
Palabras clave:
LEPTINA
,
PLACENTA
,
DIABETES
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Colecciones
Capítulos de libros(IQUIBICEN)
Capítulos de libros de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Capítulos de libros de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Guádix, Pilar; Pérez Pérez, Antonio; Vilariño, Teresa; Dueñas, Jose L.; Maymo, Julieta Lorena; et al.; Leptin and Gestational Diabetes Mellitus; IntechOpen; 2019; 55-70
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