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dc.contributor.author
Pírez, Nicolas  
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Bernabei Cornejo, Sofia Gala  
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Fernández Acosta, Magdalena  
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Duhart, José Manuel  
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Ceriani, Maria Fernanda  
dc.date.available
2021-01-22T12:39:49Z  
dc.date.issued
2019-01  
dc.identifier.citation
Pírez, Nicolas; Bernabei Cornejo, Sofia Gala; Fernández Acosta, Magdalena; Duhart, José Manuel; Ceriani, Maria Fernanda; Contribution of non-circadian neurons to the temporal organization of locomotor activity; Company of Biologists; Biology Open; 8; 1; 1-2019; 1-13  
dc.identifier.issn
2046-6390  
dc.identifier.uri
http://hdl.handle.net/11336/123448  
dc.description.abstract
In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has showed that these neurons undergo structural remodeling on their axonal projections on a daily basis. Such remodeling endows sLNvs with the possibility to make synaptic contacts with different partners at different times throughout the day, as has been previously described. By using different genetic tools to alter membrane excitability of the sLNv putative postsynaptic partners, we tested their functional role in the control of locomotor activity. We also used optical imaging to test the functionality of these contacts. We found that these different neuronal groups affect the consolidation of rhythmic activity, suggesting that non-circadian cells are part of the circuit that controls locomotor activity. Our results suggest that new neuronal groups, in addition to the well-characterized clock neurons, contribute to the operations of the circadian network that controls locomotor activity in D. melanogaster.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Company of Biologists  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
CONNECTIVITY  
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DROSOPHILA  
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LOCOMOTOR RHYTHMS  
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NON-CIRCADIAN NEURONS  
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SLNVS  
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Biología  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Contribution of non-circadian neurons to the temporal organization of locomotor activity  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-04-24T17:58:17Z  
dc.journal.volume
8  
dc.journal.number
1  
dc.journal.pagination
1-13  
dc.journal.pais
Reino Unido  
dc.description.fil
Fil: Pírez, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.description.fil
Fil: Bernabei Cornejo, Sofia Gala. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Fernández Acosta, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.description.fil
Fil: Duhart, José Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.description.fil
Fil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.journal.title
Biology Open  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1242/bio.039628