Artículo
Brain oxidative stress in the chronic overloads of iron and copper in rats.
Musacco Sebio, Rosario Natalia
; Ferrarotti, Nidia Fatima; Lairion, Fabiana Norma; Saporito Magriñá, Christian Martín
; Fuda, Julián Andrés; Torti, Horacio Emilio; Boveris, Alberto Antonio
; Repetto, Marisa Gabriela
Fecha de publicación:
12/2019
Editorial:
Elsevier Science Inc
Revista:
Journal of Inorganic Biochemistry
ISSN:
0162-0134
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Male rats of 80–90 g that were fed 42 days with a commercial rodent diet of 2780 kcal/100 g and received chronic overloads of either Fe(II) or Cu(II) in the drinking water. The two metals produced brain oxidative stress and damage with marked increases in the indicators of oxidative processes: in vivo brain surface chemiluminescence (the sensitive organ non-invasive assay for oxidative free radical reactions), and the ex vivo processes of phospholipid peroxidation and protein oxidation. Brain redox imbalance was also indicated by marked decreases in the cellular indicators of oxidative metabolic stress: reduced glutathione (GSH) content and reduced/oxidized glutathione ratio (GSH/GSSG). Brain decreased GSH content has a central role in the biochemical oxidative processes associated with Fe and Cu chronic damage. The understanding of biochemical oxidative imbalances in the rat brain with chronic Fe(II) or Cu(II) overloads may be useful for the establishment of pharmacological therapies for human pathologies associated to Fe and Cu cellular imbalances.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
Musacco Sebio, Rosario Natalia; Ferrarotti, Nidia Fatima; Lairion, Fabiana Norma; Saporito Magriñá, Christian Martín; Fuda, Julián Andrés; et al.; Brain oxidative stress in the chronic overloads of iron and copper in rats.; Elsevier Science Inc; Journal of Inorganic Biochemistry; 199; 12-2019; 1-7
Compartir
Altmétricas