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dc.contributor.author
Vitale, Daiana Luján
dc.contributor.author
Kumar Katakam, Sampath
dc.contributor.author
Greve, Burkhard
dc.contributor.author
Jang, Bohee
dc.contributor.author
Oh, Eok Soo
dc.contributor.author
Alaniz, Laura Daniela
dc.contributor.author
Götte, Martin
dc.date.available
2021-01-21T13:02:36Z
dc.date.issued
2019-06-23
dc.identifier.citation
Vitale, Daiana Luján; Kumar Katakam, Sampath; Greve, Burkhard; Jang, Bohee; Oh, Eok Soo; et al.; Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance; Wiley Blackwell Publishing, Inc; Febs Journal; 286; 15; 23-6-2019; 2870-2882
dc.identifier.issn
1742-464X
dc.identifier.uri
http://hdl.handle.net/11336/123280
dc.description.abstract
In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance proteins, active DNA repair capacity, apoptosis resistance, and a considerable developmental plasticity. Due to these properties, cancer stem cells display increased resistance to chemo- and radiotherapy. Recent findings indicate that aberrant functions of proteoglycans and glycosaminoglycans contribute substantially to the cancer stem cell phenotype and therapeutic resistance. In this review, we summarize how the diverse functions of the glycoproteins and carbohydrates facilitate acquisition and maintenance of the cancer stem cell phenotype, and how this knowledge can be exploited to develop novel anti-cancer therapies. For example, the large transmembrane chondroitin sulfate proteoglycan NG2 / CSPG4 marks stem cell populations in brain tumors. Cell surface heparan sulfate proteoglycans of the syndecan and glypican families modulate the stemness-associated Wnt, hedgehog and notch signaling pathways, whereas the interplay of hyaluronan in the stem cell niche with cancer stem cell CD44 determines maintenance of stemness and promotes therapeutic resistance. A better understanding of the molecular mechanisms by which proteoglycans and glycosaminoglycans regulate cancer stem cell function will aid the development of targeted therapeutic approaches which could avoid relapse after an otherwise successful conventional therapy. Chimeric antigen receptor T cells, proteoglycan-primed dendritic cells, proteoglycan-targeted antibody-drug conjugates and inhibitory peptides and glycans have already shown highly promising results in preclinical models.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CANCER STEM CELL
dc.subject
HEPARAN SULFATE
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HYALURONAN
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CD44
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SYNDECAN
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CSPG4
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STEM CELL NICHE
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CHEMOTHERAPY
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PROTEOGLYCAN
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RADIATION
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-01-13T16:21:12Z
dc.identifier.eissn
1432-1033
dc.journal.volume
286
dc.journal.number
15
dc.journal.pagination
2870-2882
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Kumar Katakam, Sampath. Münster University Hospital; Alemania
dc.description.fil
Fil: Greve, Burkhard. Münster University Hospital; Alemania
dc.description.fil
Fil: Jang, Bohee. Ewha Womans University; Corea del Sur
dc.description.fil
Fil: Oh, Eok Soo. Ewha Womans University; Corea del Sur
dc.description.fil
Fil: Alaniz, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Götte, Martin. Münster University Hospital; Alemania
dc.journal.title
Febs Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14967
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/febs.14967
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