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dc.contributor.author
Fernández, Diego Carlos
dc.contributor.author
Chianelli, Mónica Silvia
dc.contributor.author
Rosenstein, Ruth Estela
dc.date.available
2021-01-20T17:49:50Z
dc.date.issued
2009-12
dc.identifier.citation
Fernández, Diego Carlos; Chianelli, Mónica Silvia; Rosenstein, Ruth Estela; Involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by post-conditioning.; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 111; 2; 12-2009; 488-498
dc.identifier.issn
0022-3042
dc.identifier.uri
http://hdl.handle.net/11336/123219
dc.description.abstract
Retinal ischemia could provoke blindness and there is no effective treatment against retinal ischemic damage. Brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina from ischemia/reperfusion injury. Multiple evidences support that glutamate is implicated in retinal ischemic damage. We investigated the involvement of glutamate clearance in postconditioning-induced protection. For this purpose, ischemia was induced by increasing intraocular pressure for 40 min, and 5 min after reperfusion, animals underwent 7 cycles of 1min/1min ischemia/reperfusion. One, 3, or 7 days after ischemia, animals were subjected to electroretinography and histological analysis. The functional and histological protection induced by postconditioning was evident at 7 (but not 1 or 3) days post-ischemia. An increase in Müller cell glial fibrillary acidic protein (GFAP) levels was observed at 1, 3, and 7 days after ischemia, whereas postconditioning reduced Müller cells GFAP levels at 3 and 7 days post-ischemia. Three days after ischemia, a significant decrease in glutamate uptake and glutamine synthetase activity was observed, whereas postconditioning reversed the effect of ischemia. The intravitreal injection of supraphysiological levels of glutamate mimicked electroretinographic and histological alterations provoked by ischemia, which were abrogated by postconditioning. These results support the involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by postconditioning.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
RETINA
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ISCHEMIA
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POSTCONDITIONING
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GLUTAMATE
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Oftalmología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by post-conditioning.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-11T19:45:56Z
dc.journal.volume
111
dc.journal.number
2
dc.journal.pagination
488-498
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Fernández, Diego Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: Chianelli, Mónica Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: Rosenstein, Ruth Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.journal.title
Journal of Neurochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2009.06334.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1471-4159.2009.06334.x
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