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dc.contributor.author
Bisagno, Veronica
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dc.contributor.author
Cadet, Jean Lud
dc.date.available
2021-01-19T13:12:25Z
dc.date.issued
2019-03
dc.identifier.citation
Bisagno, Veronica; Cadet, Jean Lud; Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs; Pergamon-Elsevier Science Ltd; Neurochemistry International; 124; 3-2019; 10-18
dc.identifier.issn
0197-0186
dc.identifier.uri
http://hdl.handle.net/11336/123007
dc.description.abstract
Although some of the clinical manifestations of substance use disorders might be superficially similar, it is highly likely that different classes of abused drugs including opioids (heroin, morphine, and oxycodone, other opioids) and psychostimulants (cocaine and amphetamines) cause different neuroadaptations in various brain regions dependent in the distribution and concentration of their biochemical sites of actions. In fact, different molecular networks are indeed impacted by acute and chronic administration of addictive substances. Some of the genes whose expression is influenced by the administration of these substances are immediate-early genes (IEGs). IEGs include classes of low expression genes that can become very highly induced within seconds or minutes of activation by endogenous or exogenous stimuli. These IEGs might play important roles in activating target genes that regulate adaptations implicated in the behavioral manifestations diagnosed as addiction. Therefore, the purpose of this review is to provide an overview of recent data on the effects of psychostimulants and opioids on IEG expression in the brain. The review documents some contrasting effects of these classes of drugs on gene expression and indicates that further studies are necessary to identify the specific effects of each drug class when trying to predict clinical responses to therapeutic agents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
IMMEDIATE EARLY GENES (IEGS)
dc.subject
OPIOID
dc.subject
PSYCHOSTIMULANT
dc.subject.classification
Farmacología y Farmacia
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T17:34:51Z
dc.journal.volume
124
dc.journal.pagination
10-18
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Cadet, Jean Lud. National Institute On Drug Abuse; Estados Unidos
dc.journal.title
Neurochemistry International
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0197018618305163?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuint.2018.12.004
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