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dc.contributor.author
Martínez, Juan José
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dc.contributor.author
Tula Molina, Marcos Felipe
dc.contributor.author
Sánchez, Luis Adrián
dc.contributor.author
Deus, María Inés
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dc.contributor.author
Ramella, María Isabel
dc.contributor.author
Maurín, Gladys Beatriz
dc.contributor.author
Martínez, Gustavo
dc.contributor.author
Chernomoretz, Ariel
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dc.contributor.author
Escobar, María Soledad
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Sibilla, Gustavo
dc.contributor.author
Miozzo, María Cecilia
dc.date.available
2021-01-19T02:21:32Z
dc.date.issued
2019-10
dc.identifier.citation
Martínez, Juan José; Tula Molina, Marcos Felipe; Sánchez, Luis Adrián; Deus, María Inés; Ramella, María Isabel; et al.; First-degree familial relationships coincidences in a population database of Jujuy (Argentina) compared with simulated populations; Elsevier Science; Forensic Science International: Genetics Supplement Series; 7; 1; 10-2019; 714-715
dc.identifier.issn
1875-1768
dc.identifier.uri
http://hdl.handle.net/11336/122976
dc.description.abstract
Jujuy, a province from Northwestern Argentina, has a population with a great input of the Native American gene pool together with European and African contributions. For forensic purposes, a frequency population database was built by selecting 500 nonrelated individuals from Jujuy province and genotyping them with 21 autosomal STRs from the kit GlobalFiler™. The genetic profiles were incorporated in GENis (software developed in Argentina for storage and comparison of DNA profiles) to corroborate the lack of matches under high stringency. After this confirmation, we performed a searching strategy with low stringency, often used to find parent-child relationships. As a result, four (4) adventitious matches were found. One hundred (100) populations were simulated; with 500 random genetic profiles each one, using Jujuy allele frequencies. The coincidences for these populations were on average 2.07 (95% CI: 1.77–2.36) and there were no significant differences between Jujuy and the simulated populations. It is known that the number of adventitious matches increases when you go down with search stringency in DNA databases. Thus, care should be taken when searching for first-degree relationships, even with a high number of markers. LR calculations and complementary studies (such as extra autosomal markers, Y chromosome, and mitochondrial DNA) should be performed in this kind of search.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DNA DATABASES
dc.subject
SIMULATED POPULATIONS
dc.subject
ADVENTITIOUS MATCHES
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JUJUY
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ARGENTINA
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LOW STRINGENCY SEARCH
dc.subject.classification
Genética y Herencia
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
First-degree familial relationships coincidences in a population database of Jujuy (Argentina) compared with simulated populations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T20:45:02Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
714-715
dc.journal.pais
Países Bajos
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dc.description.fil
Fil: Martínez, Juan José. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; Argentina
dc.description.fil
Fil: Tula Molina, Marcos Felipe. Laboratorio Regional de Genética Forense del Noa; Argentina
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Fil: Sánchez, Luis Adrián. Laboratorio Regional de Genética Forense del Noa; Argentina
dc.description.fil
Fil: Deus, María Inés. Laboratorio Regional de Genética Forense del Noa; Argentina
dc.description.fil
Fil: Ramella, María Isabel. Laboratorio Regional de Genética Forense del Noa; Argentina
dc.description.fil
Fil: Maurín, Gladys Beatriz. Laboratorio Regional de Genética Forense del Noa; Argentina
dc.description.fil
Fil: Martínez, Gustavo. Servicio de Genética Forense y Registro Provincial de Datos Genéticos; Argentina
dc.description.fil
Fil: Chernomoretz, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Escobar, María Soledad. Fundación Sadosky; Argentina
dc.description.fil
Fil: Sibilla, Gustavo. Fundación Sadosky; Argentina
dc.description.fil
Fil: Miozzo, María Cecilia. Laboratorio Regional de Genética Forense del Noa; Argentina
dc.journal.title
Forensic Science International: Genetics Supplement Series
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.fsigss.2019.10.148
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1875176819303816
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