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dc.contributor.author
Davel, Lilia Elena
dc.contributor.author
Jasnis, Maria Adela
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de la Torre, Eulalia
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Gotoh, Tomomi
dc.contributor.author
Diament, Miriam
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Magenta, Gabriela Viviana
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Sacerdote de Lustig, Eugenia
dc.contributor.author
Sales, María Elena
dc.date.available
2021-01-13T21:51:55Z
dc.date.issued
2002-12-04
dc.identifier.citation
Davel, Lilia Elena; Jasnis, Maria Adela; de la Torre, Eulalia; Gotoh, Tomomi; Diament, Miriam; et al.; Arginine metabolic pathways involved in the modulation of tumor‐induced angiogenesis by macrophages; Wiley; FEBS Letters; 532; 1-2; 4-12-2002; 216-220
dc.identifier.uri
http://hdl.handle.net/11336/122700
dc.description.abstract
Neovascularization, an essential step for tumor progression and metastasis development, can be modulated by the presence of macrophages (Mps) in the tumor microenvironment. The ability of Mps to regulate the angiogenicity of the LMM3 tumor cell line was studied. Peritoneal Mps from LMM3 tumor‐bearing mice (TMps) potentiate in vivo LMM3 angiogenicity. These results were confirmed by CD31 immunoblotting assays. The activity of TMps depended on nitric oxide synthase (NOS) and arginase (A) activity. By immunoblotting we evidenced that AI and AII isoforms were up‐regulated in TMps while the inducible and neuronal NOS isoforms were highly expressed in normal Mps. TMps might positively modulate tumor growth by stimulating angiogenic cascade mainly through polyamine synthesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TUMOR ANGIOGENESIS
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MACROPHAGE
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ARGINASE
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CD31
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NITRIC OXIDE SYNTHASE
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SACERDOTE INVESTIGADORA
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PUBLICACIONES
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Arginine metabolic pathways involved in the modulation of tumor‐induced angiogenesis by macrophages
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
dc.identifier.eissn
1873-3468
dc.journal.volume
532
dc.journal.number
1-2
dc.journal.pagination
216-220
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Davel, Lilia Elena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Jasnis, Maria Adela. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: de la Torre, Eulalia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gotoh, Tomomi. Kumamoto University. School of Medicine; Japón
dc.description.fil
Fil: Diament, Miriam. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Magenta, Gabriela Viviana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sales, María Elena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.journal.title
FEBS Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1016/S0014-5793%2802%2903682-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/S0014-5793(02)03682-7
dc.provenance
Otro
dc.format.espacioDeColor
EscalaGris
dc.format.compresion
No especifica
dc.description.nivelDescripcion
Unidad documental simple
dc.type.subtype
Artículo científico
dc.type
info:ar-repo/semantics/artículo
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