Artículo
Neural cell adhesion molecule in human serum. Increased levels in dementia of the Alzheimer type
Todaro, Laura Beatriz
; Puricelli, Lydia Ines
; Gioseffi, Hernan; Pallotta, María Guadalupe; Lastiri, José; Bal de Kier Joffe, Elisa; Varela, Mirta; Sacerdote de Lustig, Eugenia
Fecha de publicación:
03/2004
Editorial:
Elsevier
Revista:
Neurobiology of Disease
ISSN:
0969-9961
Idioma:
Inglés
Volumen:
15
Número:
2
Páginas:
387-393
Subtipo:
Artículo científico
Clasificación temática:
Resumen
Memory impairment is a process associated with alterations in neuronal plasticity, synapses formation, and stabilization. As the neural cell adhesion molecule (NCAM) plays a key role in synaptic bond stabilization, we analyzed the usefulness of soluble NCAM isoforms in the diagnosis of patients with dementia of the Alzheimer type (DAT). NCAM was measured in the sera of 70 control subjects and 43 DAT patients (with different severity of cognitive impairment, GDS), employing Western blot and densitometric quantification. LMW-NCAM bands (100–130 kDa) decreased significantly with age independently of sex. DAT patients presented values of LMW-NCAM and HMW-NCAM significantly higher than healthy controls of similar age (higher than 130 kDa). Only LMW-NCAM was associated with GDS. Our results suggest that NCAM could be involved in the pathogenesis of DAT disorder and that serum NCAM levels could be useful as differential diagnostic markers of the disease.
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Recursos continuos (Eugenia Sacerdote)
Recursos continuos (Eugenia Sacerdote)
Recursos continuos (Eugenia Sacerdote)
Citación
Todaro, Laura Beatriz; Puricelli, Lydia Ines; Gioseffi, Hernan; Pallotta, María Guadalupe; Lastiri, José; et al.; Neural cell adhesion molecule in human serum. Increased levels in dementia of the Alzheimer type; Elsevier; Neurobiology of Disease; 15; 2; 3-2004; 387-393
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