Mostrar el registro sencillo del ítem

dc.contributor.author
Galli, S.  
dc.contributor.author
Colombo, Lucas Luis  
dc.contributor.author
Vanzuli, Silvia  
dc.contributor.author
Daroqui, Maria Cecilia  
dc.contributor.author
Vidal, María del Carmen C.  
dc.contributor.author
Jasnis, Maria Adela  
dc.contributor.author
Sacerdote de Lustig, Eugenia  
dc.contributor.author
Eijan, Ana Maria  
dc.date.available
2021-01-13T19:09:59Z  
dc.date.issued
2000-12  
dc.identifier.citation
Galli, S.; Colombo, Lucas Luis; Vanzuli, Silvia; Daroqui, Maria Cecilia; Vidal, María del Carmen C.; et al.; Characterization of a fibroblastoid mammary carcinoma cell line (LM2) originated from a mouse adenocarcinoma; Spandidos Publications; International Journal of Oncology; 17; 6; 12-2000; 1259-1324  
dc.identifier.issn
1019-6439  
dc.identifier.uri
http://hdl.handle.net/11336/122637  
dc.description.abstract
We established and characterized a new mammary tumor cell line, LM2, derived from M2 mammary adenocarcinoma which spontaneously appeared in a BALB/c female mouse. The LM2 cell line has been maintained in culture for more than 40 passages and grows as poorly differentiated elongated cells. Ultrastructural and immunocytochemistry analysis revealed characteristic features of adenocarcinoma. Cytogenetic studies showed that LM2 cells are fundamentally hypotetraploid. They express metalloproteinases (MMP) and show high levels of plasminogen activator type urokinase (uPA). They were sensitive to nitric oxide (NO)-mediated cytotoxicity when NO derived from an exogenous donor. In vivo, although LM2 cells were able to grow in the lungs, they could not metastasize to the same target organ from s.c. primary tumors. The LM2 mouse mammary adenocarcinoma cell line is a suitable model to examine different aspects of tumor biology, in particular those related to the different pathways involved in the metastatic cascade and in the cytotoxicity mediated by NO.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Spandidos Publications  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
MURINE CARCINOMA  
dc.subject
METÁSTASIS  
dc.subject
PLASMINOGEN ACTIVATOR  
dc.subject
METALLOPROTEINASES  
dc.subject
NITRIC OXIDE  
dc.subject
SACERDOTE INVESTIGADORA  
dc.subject
PUBLICACIONES  
dc.subject.classification
Oncología  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Characterization of a fibroblastoid mammary carcinoma cell line (LM2) originated from a mouse adenocarcinoma  
dc.type
info:eu-repo/semantics/article  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.identifier.eissn
1791-2423  
dc.journal.volume
17  
dc.journal.number
6  
dc.journal.pagination
1259-1324  
dc.journal.pais
Grecia  
dc.journal.ciudad
Atenas  
dc.description.fil
Fil: Galli, S.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Vanzuli, Silvia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Daroqui, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Vidal, María del Carmen C.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Jasnis, Maria Adela. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Eijan, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.journal.title
International Journal of Oncology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/ijo.17.6.1259  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3892/ijo.17.6.1259  
dc.provenance
Otro  
dc.format.espacioDeColor
EscalaGris  
dc.format.compresion
No especifica  
dc.description.nivelDescripcion
Unidad documental simple  
dc.type.subtype
Artículo científico  
dc.type
info:ar-repo/semantics/artículo