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dc.contributor.author
Casero, Carina Noelia
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dc.contributor.author
Estévez-Braun, Ana
dc.contributor.author
Gutiérrez Ravelo, Ángel
dc.contributor.author
Demo, Mirta
dc.contributor.author
Méndez Alvarez, Sabastián
dc.contributor.author
Machin, Félix
dc.date.available
2017-01-31T17:17:54Z
dc.date.issued
2013-02
dc.identifier.citation
Casero, Carina Noelia; Estévez-Braun, Ana; Gutiérrez Ravelo, Ángel; Demo, Mirta; Méndez Alvarez, Sabastián; et al.; Achyrofuran is a strong antibacterial agent capable of killing Methicillin- Vancomycinresistant Staphylococcus aureus in the nanomolar range; Elsevier Gmbh; Phytomedicine; 20; 2; 2-2013; 133-138
dc.identifier.issn
0944-7113
dc.identifier.uri
http://hdl.handle.net/11336/12235
dc.description.abstract
Currently, there is a pressing need for novel antibacterial agents against drug-resistant bacteria, especially those which have been common in our communities and hospitals, such as methicillin-resistant Staphylococcus aureus (MRSA). The South American plant Achyrocline satureioides (Marcela) has been widely used in traditional medicine for a number of diseases, including infections. Several crude extracts from this plant have shown good antimicrobial activities in vitro. In the search for the active principle (s) that confers these antimicrobial activities, we have processed the dichloromethane extract from the aerial parts of the plant. One of the isolated compounds showed extraordinary antibacterial activities against a set of clinically relevant Gram-positive strains that widely differ in their antibiogram profiles. This compound was identified as achyrofuran on the basis of its spectroscopic and physical data.<br />We determined the MIC to be around 0.1 M (0.07 g/ml) for the reference methicillin-resistant and<br />vancomycin-intermediate S. aureus strain NRS402. Moreover, nanomolar concentrations of achyrofuran killed 10 6 bacteria within 12 h. Based on the presence of the 2,2-biphenol core, we further studied whether achyrofuran killed bacteria through a mechanism of action similar to that reported for the naturally occurring antibiotic MC21-A. Indeed, we found that achyrofuran was not bacteriolytic by itself although it greatly compromised membrane impermeability as determined by increased SYTOX Green uptake.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Gmbh
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Achyrocline Satureioides
dc.subject
Staphylococcus Aureus
dc.subject
Mrsa
dc.subject
Phytoalexins
dc.subject
Achyrofuran
dc.subject
Antimicrobial
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Achyrofuran is a strong antibacterial agent capable of killing Methicillin- Vancomycinresistant Staphylococcus aureus in the nanomolar range
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-12T14:16:52Z
dc.journal.volume
20
dc.journal.number
2
dc.journal.pagination
133-138
dc.journal.pais
Alemania
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dc.description.fil
Fil: Casero, Carina Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Rio Cuarto; Argentina. Universidad de la Laguna; España
dc.description.fil
Fil: Estévez-Braun, Ana. Universidad de la Laguna; España. Instituto Canario de Investigación del Cáncer; España
dc.description.fil
Fil: Gutiérrez Ravelo, Ángel. Universidad de la Laguna; España. Instituto Canario de Investigación del Cáncer; España
dc.description.fil
Fil: Demo, Mirta. Universidad Nacional de Rio Cuarto; Argentina
dc.description.fil
Fil: Méndez Alvarez, Sabastián. Universidad de la Laguna; España. Hospital Universitario Nuestra Señora de Candelaria; España
dc.description.fil
Fil: Machin, Félix. Hospital Universitario Nuestra Señora de Candelaria; España
dc.journal.title
Phytomedicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phymed.2012.11.003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0944711312004060
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