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dc.contributor.author
Bianchi, Virginia Angélica
dc.contributor.author
Langeloh, Hendrick
dc.contributor.author
Tillmann, Urban
dc.contributor.author
Krock, Bernd
dc.contributor.author
Müller, Annegret
dc.contributor.author
Bickmeyer, Ulf
dc.contributor.author
Abele, Doris
dc.date.available
2021-01-07T19:50:45Z
dc.date.issued
2019-01
dc.identifier.citation
Bianchi, Virginia Angélica; Langeloh, Hendrick; Tillmann, Urban; Krock, Bernd; Müller, Annegret; et al.; Separate and combined effects of neurotoxic and lytic compounds of Alexandrium strains on Mytilus edulis feeding activity and hemocyte function; Academic Press Ltd - Elsevier Science Ltd; Fish & Shellfish Immunology; 84; 1-2019; 414-422
dc.identifier.issn
1050-4648
dc.identifier.uri
http://hdl.handle.net/11336/121785
dc.description.abstract
Multiple toxic and bioactive compounds produced by Alexandrium spp. cause adverse effects on bivalves, but these effects are frequently difficult to attribute to a single compound class. To disentangle the effect of neurotoxic vs lytic secondary metabolites, we exposed blue mussels to either a paralytic shellfish toxin (PST) producing Alexandrium spp. strain, or to an exclusively lytic compound (LC) producing strain, or a strain containing both compound classes, to evaluate the time dependent effects after 3 and 7 days of feeding. Tested parameters comprised signs of paralysis, feeding activity, and immune cell integrity (hemocyte numbers and viability; lysosomal membrane destabilization) and function (ROS production). Both compound classes caused paralysis and immune impairment. The only effect attributable exclusively to PST was increased phagocytic activity after 3 days and impaired feeding activity after 7 days, which curtailed toxin accumulation in digestive glands. Lysosomal membrane destabilization were more closely, but not exclusively, matched with LC exposure. Effects on circulating hemocyte integrity and immune related functions were mostly transient or remained stable within 7 days; except for increased lysosomal labialization and decreased extracellular ROS production when mussels were exposed to the toxin combination. M. edulis displays adaptive fitness traits to survive and maintain immune capacity upon prolonged exposure to environmentally relevant concentrations of PST and/or LC producing Alexandrium strains.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Ltd - Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BLUE MUSSEL
dc.subject
PARALYTIC SHELLFISH TOXIN
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LYTIC ACTIVITY
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FILTERING ACTIVITY
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IMMUNE RESPONSE
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Separate and combined effects of neurotoxic and lytic compounds of Alexandrium strains on Mytilus edulis feeding activity and hemocyte function
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T20:49:52Z
dc.identifier.eissn
1095-9947
dc.journal.volume
84
dc.journal.pagination
414-422
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Bianchi, Virginia Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Ecotoxicología Acuática; Argentina
dc.description.fil
Fil: Langeloh, Hendrick. Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung; Alemania
dc.description.fil
Fil: Tillmann, Urban. Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung; Alemania
dc.description.fil
Fil: Krock, Bernd. Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung; Alemania
dc.description.fil
Fil: Müller, Annegret. Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung; Alemania
dc.description.fil
Fil: Bickmeyer, Ulf. Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung; Alemania. Alfred-Wegener-Institut. Helmholtz-Zentrum für Polar und Meeresforschung; Alemania
dc.description.fil
Fil: Abele, Doris. Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung; Alemania
dc.journal.title
Fish & Shellfish Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1050464818306545
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.fsi.2018.10.024
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