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dc.contributor.author
Garcia Rill, Edgar  
dc.contributor.author
Tackett, Alan  
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Byrum, Stephanie  
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Lan, Renny  
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Mackintosh, Samuel  
dc.contributor.author
Hyde, James  
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Bisagno, Veronica  
dc.contributor.author
Urbano Suarez, Francisco Jose  
dc.date.available
2021-01-07T12:19:53Z  
dc.date.issued
2019-03  
dc.identifier.citation
Garcia Rill, Edgar; Tackett, Alan; Byrum, Stephanie; Lan, Renny; Mackintosh, Samuel; et al.; Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus; Molecular Diversity Preservation International; Brain Sciences; 9; 3; 3-2019; 1-15  
dc.identifier.issn
2076-3425  
dc.identifier.uri
http://hdl.handle.net/11336/121695  
dc.description.abstract
Our discovery of low-threshold stimulation-induced locomotion in the pedunculopontine nucleus (PPN) led to the clinical use of deep brain stimulation (DBS) for the treatment of disorders such as Parkinson's disease (PD) that manifest gait and postural disorders. Three additional major discoveries on the properties of PPN neurons have opened new areas of research for the treatment of motor and arousal disorders. The description of (a) electrical coupling, (b) intrinsic gamma oscillations, and (c) gene regulation in the PPN has identified a number of novel therapeutic targets and methods for the treatment of a number of neurological and psychiatric disorders. We first delve into the circuit, cellular, intracellular, and molecular organization of the PPN, and then consider the clinical results to date on PPN DBS. This comprehensive review will provide valuable information to explain the network effects of PPN DBS, point to new directions for treatment, and highlight a number of issues related to PPN DBS.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Molecular Diversity Preservation International  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
AROUSAL  
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CAMKII  
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cAMP  
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GAMMA ACTIVITY  
dc.subject.classification
Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-13T20:48:36Z  
dc.journal.volume
9  
dc.journal.number
3  
dc.journal.pagination
1-15  
dc.journal.pais
Suiza  
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Basilea  
dc.description.fil
Fil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Tackett, Alan. University of Arkansas for Medical Sciences; Estados Unidos  
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Fil: Byrum, Stephanie. University of Arkansas for Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Lan, Renny. University of Arkansas for Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Mackintosh, Samuel. University of Arkansas for Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Hyde, James. Southern Arkansas University; Estados Unidos  
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina  
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.journal.title
Brain Sciences  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3425/9/3/64  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/brainsci9030064