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dc.contributor.author
Fernández Bedmar, Zahira Noemí
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dc.contributor.author
Demyda Peyrás, Sebastián
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dc.contributor.author
Merinas Amo, Tania
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dc.contributor.author
del Río Celestino, Mercedes
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dc.date.available
2021-01-07T02:49:56Z
dc.date.issued
2019-06-21
dc.identifier.citation
Fernández Bedmar, Zahira Noemí; Demyda Peyrás, Sebastián; Merinas Amo, Tania; del Río Celestino, Mercedes; Nutraceutic Potential of Two Allium Species and Their Distinctive Organosulfur Compounds: A Multi-Assay Evaluation; Multidisciplinary Digital Publishing Institute; Foods; 8; 6; 21-6-2019; 1-19
dc.identifier.uri
http://hdl.handle.net/11336/121692
dc.description.abstract
This study aimed to evaluate the biological activities of two Allium species (garlic and onion) as well as diallyl disulphide (DADS) and dipropyl disulphide (DPDS) as their representative bioactive compounds in a multi-assay experimental design. The genotoxic, antigenotoxic, and lifespan eects of garlic, onion, DADS, and DPDS were checked in Drosophila melanogaster and their cytotoxic, pro-apoptotic, and DNA-clastogenic activities were analyzed using HL60 tumoral cells. All compounds were non-genotoxic and antigenotoxic against H2O2-induced DNA damage with a positive dose-response effect and different inhibition percentages (the highest value: 95% for DADS) at all tested concentrations. Daily intake of Allium vegetables, DADS, or DPDS had no positive effects on flies’ lifespan and health span. Garlic and DADS exerted the highest cytotoxic effects in a positive dose-dependent manner. Garlic and DADS exerted a DNA-internucleosomal fragmentation as an index of induced proapoptotic activity on HL60 cells. Allium vegetables and DADS were able to induce clastogenic strand breaks in the DNA of HL60 cells. This study showed the genomic safety ofthe assayed substances and their protective genetic effects against the hydrogen peroxide genotoxine. Long-term treatments during the whole life of the Drosophila genetic model were beneficial only at low-median concentrations. The chemo-preventive activity of garlic could be associated with its distinctive organosulfur DADS. We suggest that supplementary studies are needed to clarify the cell death pathway against garlic and DADS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
garlic
dc.subject
onion
dc.subject
antigenotoxicity
dc.subject
longevity
dc.subject
citotoxicity
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Nutraceutic Potential of Two Allium Species and Their Distinctive Organosulfur Compounds: A Multi-Assay Evaluation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T16:20:10Z
dc.identifier.eissn
2304-8158
dc.journal.volume
8
dc.journal.number
6
dc.journal.pagination
1-19
dc.journal.pais
Suiza
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dc.journal.ciudad
basel
dc.description.fil
Fil: Fernández Bedmar, Zahira Noemí. Universidad de Córdoba; España
dc.description.fil
Fil: Demyda Peyrás, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Merinas Amo, Tania. Universidad de Córdoba; España
dc.description.fil
Fil: del Río Celestino, Mercedes. Laboratorio agroalimentario; España
dc.journal.title
Foods
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2304-8158/8/6/222
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/foods8060222
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