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dc.contributor.author
Zuo, Ran
dc.contributor.author
Oliveira, Aline de
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Bullita, Enrica
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Torino, Maria Ines
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Padgett Pagliai, Kaylie A.
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Gardner, Christopher L.
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Harrison, Natalie A.
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Silva, Danilo da
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Merli, Marcelo Luciano
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Gonzalez, Claudio Fabricio
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dc.contributor.author
Lorca, Graciela L.
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dc.date.available
2021-01-06T17:32:52Z
dc.date.issued
2019-10-20
dc.identifier.citation
Zuo, Ran; Oliveira, Aline de; Bullita, Enrica; Torino, Maria Ines; Padgett Pagliai, Kaylie A.; et al.; Identification of flavonoids as regulators of YbeY activity in Liberibacter asiaticus; Blackwell Publishing; Environmental Microbiology; 21; 12; 20-10-2019; 4822-4835
dc.identifier.issn
1462-2912
dc.identifier.uri
http://hdl.handle.net/11336/121639
dc.description.abstract
Liberibacter asiaticus is the prevalent causative pathogen of Huanglongbing or citrus greening disease, which has resulted in a devastating crisis in the citrus industry. A thorough understanding of this pathogen´s physiology and mechanisms to control cell survival is critical in the identification of therapeutic targets. YbeY is a highly conserved bacterial RNase that has been implicated in multiple roles. In this study, we evaluated the biochemical characteristics of the L. asiaticus YbeY (CLIBASIA_01560) and assessed its potential as a target for antimicrobials. YbeYLas was characterized as an endoribonuclease with activity on 3′ and 5′ termini of 16S and 23S rRNAs, and the capacity to suppress the E. coli ΔybeY phenotype. We predicted the YbeYLas protein:ligand interface and subsequently identified a flavone compound, luteolin, as a selective inhibitor. Site‐directed mutagenesis was subsequently used to identify key residues involved in the catalytic activity of YbeYLas. Further evaluation of naturally occurring flavonoids in citrus trees indicated that both flavones and flavonols had potent inhibitory effects on YbeYLas. Luteolin was subsequently examined for efficacy against L. asiaticus in Huanglongbing‐infected citrus trees, where a significant reduction in L. asiaticus gene expression was observed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HUANGLONGBING
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LIBERIBACTER ASIATICUS
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LUTEOLIN
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Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Identification of flavonoids as regulators of YbeY activity in Liberibacter asiaticus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-03T13:22:36Z
dc.identifier.eissn
1462-2920
dc.journal.volume
21
dc.journal.number
12
dc.journal.pagination
4822-4835
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Zuo, Ran. University of Florida; Estados Unidos
dc.description.fil
Fil: Oliveira, Aline de. University of Florida; Estados Unidos
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Fil: Bullita, Enrica. University of Florida; Estados Unidos
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Fil: Torino, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. University of Florida; Estados Unidos
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Fil: Padgett Pagliai, Kaylie A.. University of Florida; Estados Unidos
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Fil: Gardner, Christopher L.. University of Florida; Estados Unidos
dc.description.fil
Fil: Harrison, Natalie A.. University of Florida; Estados Unidos
dc.description.fil
Fil: Silva, Danilo da. University of Florida; Estados Unidos
dc.description.fil
Fil: Merli, Marcelo Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Florida; Estados Unidos
dc.description.fil
Fil: Gonzalez, Claudio Fabricio. University of Florida; Estados Unidos
dc.description.fil
Fil: Lorca, Graciela L.. University of Florida; Estados Unidos
dc.journal.title
Environmental Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/1462-2920.14831
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/1462-2920.14831
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