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dc.contributor.author
Martínez Solís, María  
dc.contributor.author
Herrero, Salvador  
dc.contributor.author
Targovnik, Alexandra Marisa  
dc.date.available
2021-01-06T12:55:37Z  
dc.date.issued
2019-01  
dc.identifier.citation
Martínez Solís, María; Herrero, Salvador; Targovnik, Alexandra Marisa; Engineering of the baculovirus expression system for optimized protein production; Springer; Applied Microbiology and Biotechnology; 103; 1; 1-2019; 113-123  
dc.identifier.issn
0175-7598  
dc.identifier.uri
http://hdl.handle.net/11336/121575  
dc.description.abstract
Baculoviruses are arthropod-specific large circular double-stranded DNA viruses successfully used for the control of multipleinsect pests. In addition to their application in pest control, baculoviruses have become a versatile and powerful eukaryotic vectorfor the production of large quantities of recombinant proteins for research and biomedical purposes. Since the first recombinantprotein was expressed in 1983 using the baculovirus expression system (BEVS), different strategies have been developed for thegeneration of recombinant viruses and to increase the stability, yield, and posttranslational modifications of recombinant proteins.In this review, we summarize the main methods and elements playing a role in the BEVS emphasizing recent progresses andfuture developments with respect to the main aspects involved in protein production using the BEVS.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
NUCLEOPOLYHEDROVIRUS  
dc.subject
PROTEIN EXPRESSION  
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INSECT CELLS  
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INSECT BIOFACTORY  
dc.subject.classification
Biotecnología Industrial  
dc.subject.classification
Biotecnología Industrial  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Engineering of the baculovirus expression system for optimized protein production  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-12-17T19:15:46Z  
dc.identifier.eissn
1432-0614  
dc.journal.volume
103  
dc.journal.number
1  
dc.journal.pagination
113-123  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlin  
dc.description.fil
Fil: Martínez Solís, María. Universidad de Valencia. Estructura de Investigación Interdisciplinar en Biotecnología y Biomedicina; España  
dc.description.fil
Fil: Herrero, Salvador. Universidad de Valencia. Estructura de Investigación Interdisciplinar en Biotecnología y Biomedicina; España  
dc.description.fil
Fil: Targovnik, Alexandra Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina. Universidad de Valencia. Estructura de Investigación Interdisciplinar en Biotecnología y Biomedicina; España  
dc.journal.title
Applied Microbiology and Biotechnology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00253-018-9474-7  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00253-018-9474-7  

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