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Artículo

Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo

Argañaraz, Martin EduardoIcon ; Zampini, RenatoIcon ; Apichela, Silvana AndreaIcon ; Barraza, Daniela EstefaníaIcon ; Angiono, Georgina Melisa; Lombardo, Daniel Marcelo
Fecha de publicación: 11/2019
Editorial: Wiley
Revista: Molecular Reproduction and Development
ISSN: 1040-452X
e-ISSN: 1098-2795
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Reproductiva

Resumen

To gain further insight in the mechanisms of the embryo–maternal dialog in the oviduct, expression of members of the transforming growth factor‐β superfamily, NODAL, its inhibitor, LEFTY2, and their coreceptor, CFC1, were studied in the oviduct of 3‐day post copula (3 dpc) females with and without embryos (E and NE), pseudopregnant rats (SP3), and in 3‐day embryos. Nodal transcripts in SP3 oviducts showed a steady‐state relative abundance when compared with proestrus stage and the 3 dpc. In contrast, Lefty2 and Cfc1 relative abundance levels in proestrus and 3 dpc were higher. When comparing E with NE oviducts, Nodal and Lefty2 expression levels decreased, while Cfc1 expression increased in the presence of embryos. Nodal messenger RNA (mRNA) was observed in the embryo, but Lefty2 and Cfc1 transcripts were not found. In addition, an increase in Lefty2 expression coincided with increased levels of matrix metalloproteinases 9 mRNA and protein in the oviduct and in the oviductal fluid, respectively. These observations have shed new light on the relevance of the NODAL/LEFTY2 pathway in the oviduct during early embryo development and the role of the embryo in modulating this pathway.
Palabras clave: EMBRYO , LEFTY2 , NODAL , OVIDUCT
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/121569
DOI: http://dx.doi.org/10.1002/mrd.23254
URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrd.23254
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Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Argañaraz, Martin Eduardo; Zampini, Renato; Apichela, Silvana Andrea; Barraza, Daniela Estefanía; Angiono, Georgina Melisa; et al.; Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo; Wiley; Molecular Reproduction and Development; 86; 11; 11-2019; 1652-1662
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