Artículo
Temporins: An Approach of Potential Pharmaceutic Candidates
Romero, Stella Maris
; Cardillo, Alejandra Beatriz
; Martínez Ceron, María Camila
; Camperi, Silvia Andrea
; Giudicessi, Silvana Laura
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Fecha de publicación:
12/2019
Editorial:
Mary Ann Liebert
Revista:
Surgical Infections
ISSN:
1096-2964
e-ISSN:
1557-8674
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are small and mostlypolycationic molecules that form part of the innate immune response. There are currently more than3000 experimentally reported AMPs. Particularly, in frogs, the temporin family, have beendiscovered as potential AMPs. The aim of this work is to review the latest publications about thisclass of peptides, discuss their properties and make an update of the last studies and new discoveriesin the field.More than 130 temporins have been identified in this family. The most studied temporins aretemporin A (TA), temporin B (TB) and temporin L (TL). These peptides showed antimicrobialactivity against Gram-negative, Gram-positive bacteria and fungi. Since the discovery of temporinsin 1996, several groups of research isolated different peptides from various species of frogs thatwere included as members of this family. Although antimicrobial activity of many temporins has not been analyzed yet, most of them showed antimicrobial and antifungal activities. Combination ofnanotechnology and AMPs as temporins in different antimicrobial treatments could be a promisingalternative for resistance pathogens. These studies demonstrate that, even with the advancement inscientific research on the composition and antimicrobial activity of temporins, further studies arenecessary to wholly understand their components and mechanisms of action.
Palabras clave:
antimicrobial peptides
,
antifungals
,
drug delivery
,
frog
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Identificadores
Colecciones
Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos(NANOBIOTEC)
Articulos de INSTITUTO DE NANOBIOTECNOLOGIA
Articulos de INSTITUTO DE NANOBIOTECNOLOGIA
Citación
Romero, Stella Maris; Cardillo, Alejandra Beatriz; Martínez Ceron, María Camila; Camperi, Silvia Andrea; Giudicessi, Silvana Laura; Temporins: An Approach of Potential Pharmaceutic Candidates; Mary Ann Liebert; Surgical Infections; 21; 4; 12-2019; 309-322
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