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dc.contributor.author
Prince, Paula Denise
dc.contributor.author
Fraga, César Guillermo
dc.contributor.author
Galleano, Mónica Liliana
dc.date.available
2021-01-04T21:34:29Z
dc.date.issued
2019-11-05
dc.identifier.citation
Prince, Paula Denise; Fraga, César Guillermo; Galleano, Mónica Liliana; (–)-Epicatechin administration protects kidney against modifications induced by short-term L-NAME treatment in rats; Royal Society of Chemistry; Food and Function; 11; 1; 5-11-2019; 318-327
dc.identifier.issn
2042-650X
dc.identifier.uri
http://hdl.handle.net/11336/121436
dc.description.abstract
The aim of this work was to evaluate the protective effects of (−)-epicatechin on the kidney of NO-deprived rats. Male Sprague Dawley rats were divided into three groups: control (C), receiving water and standard diet; L-NAME (L), receiving a solution of N(ω)-nitro-L-arginine methyl ester (L-NAME) (360 mg/l in water) as beverage and standard diet; and L-NAME-(−)-epicatechin (LE), receiving L-NAME solution as beverage and standard diet added with (?)-epicatechin (4 g/kg diet). The L-group showed altered kidney function parameters, evaluated as plasma urea and creatinine. In parallel, kidney oxidative stress markers, i.e. superoxide anion production, malondyaldehide content, and 3-nitrotyrosine-protein adducts were significantly increased in the L group. In addition, L-NAME treatment induced modifications in kidney NO bioavailability determinants: increased expression of NOXs subunits (p47phox, gp91phox, NOXO1, NOX4), and lowered NOS activity. (−)-Epicatechin administration restored kidney function parameters, oxidative stress markers, expression of p47phox, gp91phox, and NOX4 and NOS activity to control values. These results indicate that (−)-epicatechin can mitigate NO-mediated impairment of kidney function, in part due to its capacity to modulate NOXs, NOSs, and consequently oxidative stress and NO bioavailability.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIOXIDANTS
dc.subject
FLAVONOIDS
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NADPH OXIDASE
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OXIDATIVE STRESS
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SUPEROXIDE
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
(–)-Epicatechin administration protects kidney against modifications induced by short-term L-NAME treatment in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-06T20:26:39Z
dc.identifier.eissn
2042-6496
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
318-327
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Prince, Paula Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
dc.description.fil
Fil: Fraga, César Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de California; Estados Unidos
dc.description.fil
Fil: Galleano, Mónica Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina
dc.journal.title
Food and Function
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2019/FO/C9FO02234A
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/C9FO02234A
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