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dc.contributor.author
Taboada, Félix Facundo
dc.contributor.author
Habib, Natalia Cecilia
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Genta, Susana Beatriz de Fátima
dc.date.available
2021-01-04T20:13:53Z
dc.date.issued
2019-12
dc.identifier.citation
Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima; Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats; Medknow Publications; International Journal of Pharmaceutical Investigation; 9; 4; 12-2019; 187-194
dc.identifier.issn
2230-973X
dc.identifier.uri
http://hdl.handle.net/11336/121423
dc.description.abstract
Background: Peptic ulcer is a disease caused by imbalance between protective and aggressive factors in the gastric mucosa. Acacia aroma Gill.ex Hook. and Arn. (tusca) is widely used in Argentinian?s folk medicine forgastrointestinal disorders. The present study was designed to evaluatethe protective effect of two A. aroma leaf extracts, 5% infusion and 10%hydroalcoholic extract in experimental models of acute gastric ulcerationin rats. Methods: The gastroprotective action of the extracts was evaluated in absolute ethanol-induced gastric lesion models in adult Westarrats through macroscopic, histological and biochemical analyses of thestomach and gastric wall. We also determined the effects on the gastricjuice parameters with a pylorus ligature model in rats. Evaluation of theacute toxicity of each extract was performed in adult normal Wistar rats.All results were statistically analyzed. Results: The lowest effective dosewas 150 mg/Kg for each extract. Both of them showed a high protectionof the mucosa against absolute ethanol. Pre-treatments with the extractsproduced a significant increase in adherent mucus. These extracts showeda free radical scavenging capacity and they caused a significant reductionof the malondialdehyde, reduced glutathione levels, catalase and myeloperoxidase activities. The animals presented no signs of acute toxicityindicating a high safety margin for both extracts. Conclusion: This studyshows for the first time the gastroprotective efficacy of 5% infusion and10% hydroalcoholic extract of A. aroma leaves, highlighting their benefitsas a prophylactic approach to maintain the integrity of the gastric mucosa.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Medknow Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACUTE TOXICITY
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ANTIOXIDANT ACTIVITY
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GASTROPROTECTION
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TUSCA
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PRECLINICAL STUDIES
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T16:40:37Z
dc.identifier.eissn
2230-9713
dc.journal.volume
9
dc.journal.number
4
dc.journal.pagination
187-194
dc.journal.pais
India
dc.journal.ciudad
Bangalore
dc.description.fil
Fil: Taboada, Félix Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Habib, Natalia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
dc.description.fil
Fil: Genta, Susana Beatriz de Fátima. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.journal.title
International Journal of Pharmaceutical Investigation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.5530/ijpi.2019.4.35
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jpionline.org/index.php/ijpi/article/view/352