Artículo
RcsB-dependent effects on nar operon regulation during the aerobic growth of Salmonella Typhimurium
Torrez Lamberti, Monica Florencia
; Ballesteros, María Florencia
; Lopez, Fabian Enrique
; Pescaretti, María de Las Mercedes
; Táquez Delgado, Mónica Alejandra
Fecha de publicación:
12/2019
Editorial:
Elsevier
Revista:
Biochimie
ISSN:
0300-9084
e-ISSN:
1638-6183
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The intracellular pathogen Salmonella is an important cause of human foodborne diseases worldwide. Salmonella takes advantage of the phosphorelay regulatory systems to survive in the hostile environment of the host´s gastrointestinal tract. It has been reported that the nitrate reductase Z (NR-Z), encoded by the narUZYV operon, is required during Salmonella transition to anaerobic environments and is constitutively produced at low levels, but little is known about the regulatory mechanism involved in the operon gene expression. In this work, we found that the RcsCDB system is activated by high concentrations of specific sugars as a carbon source. In this activation state, the RcsCDB system participates in the negative control of narUZYWV expression. This control strategy occurs during exponential growth when the carbon source is high, allowing for normal aerobic respiration. The RcsCDB system´s participation in aerobic respiration is necessary to ensure efficient metabolism and optimal energy consumption when the bacteria are growing exponentially.
Palabras clave:
RCSCDB
,
RESPIRATION
,
SALMONELLA
,
NARUZYWV
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Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Torrez Lamberti, Monica Florencia; Ballesteros, María Florencia; Lopez, Fabian Enrique; Pescaretti, María de Las Mercedes; Táquez Delgado, Mónica Alejandra; RcsB-dependent effects on nar operon regulation during the aerobic growth of Salmonella Typhimurium; Elsevier; Biochimie; 167; 12-2019; 152-161
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