Pediatric-onset psychogenic nonepileptic seizures: A retrospective international multicenter study

Abstract

Purpose: We compared various clinical characteristics of pediatric-onset psychogenic nonepileptic seizures(PNES) between patients from fie countries. The purpose of this study was to advance our understanding ofpediatric-onset PNES cross-culturally.Methods: In this retrospective study, we compared consecutive patients with PNES with an age at onset of 16years and younger from epilepsy monitoring units in Iran, Brazil, the USA, Canada, and Venezuela. Age, gender,age at seizure onset, seizure semiology, predisposing factors, and video-EEG recordings of all patients wereextracted. Pearson Chi-Square, one-way ANOVA and Bonferroni correction tests were used for statistical analyses.Results: Two hundred twenty-nine patients were studied (83 from Iran, 50 from Brazil, 39 from Canada, 30 fromthe USA, and 27 from Venezuela). Mean age at the onset of seizures was 12.1 ± 3.2 years (range: 4?16 years).The sex ratio of the patients was 1.83: 1 (148 females and 81 males). Clinical characteristics of pediatric-onsetPNES showed some signifiant diffrences among the nations. However, factors associated with pediatric-onsetPNES in these fie nations were similar.Conclusion: This study underscores how international cross-cultural studies can make important contributions toour understanding of PNES. Patients with pediatric-onset PNES from diffrent countries were similar on manyrisk factors associated with PNES. This suggests universality in many features of PNES. However, intriguingdiffrences were also noted with regard to seizure semiology, which might be the result of cultural factors.