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dc.contributor.author
Mocayar Maron, Feres Jose
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dc.contributor.author
Ferder, Leon Fernando
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dc.contributor.author
Saraví, Fernando Daniel
dc.contributor.author
Manucha, Walter Ariel Fernando
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dc.date.available
2020-12-29T20:49:53Z
dc.date.issued
2019-03
dc.identifier.citation
Mocayar Maron, Feres Jose; Ferder, Leon Fernando; Saraví, Fernando Daniel; Manucha, Walter Ariel Fernando; Hypertension linked to allostatic load: From psychosocial stress to inflammation and mitochondrial dysfunction; Taylor & Francis Ltd; Stress; 22; 2; 3-2019; 169-181
dc.identifier.issn
1025-3890
dc.identifier.uri
http://hdl.handle.net/11336/121333
dc.description.abstract
Although a large number of available treatments and strategies, the prevalence of cardiovascular diseases continues to grow worldwide.émergingévidence supports the notion of counteracting stress as a critical component of a comprehensive therapeutic strategy for cardiovascular disease. Indeed, an unhealthy lifestyle is a burden to biological variables such as plasma glucose, lipid profile, and blood pressure control. Recent findings identify allostatic load as a new paradigm for an integrated understanding of the importance of psychosocial stress and its impact on the development and maintenance of cardiovascular disease. Allostasis complement homeostasis and integrates behavioral and physiological mechanisms by which genes,éarlyéxperiences,énvironment, lifestyle, diet, sleep, and physicaléxercise can modulate and adapt biological responses at the cellular level. Foréxample, variability is a physiological characteristic of blood pressure necessary for survival and the allostatic load in hypertension can contribute to its related cardiovascular morbidity and mortality. Therefore, the current review will focus on the mechanisms that link hypertension to allostatic load, which includes psychosocial stress, inflammation, and mitochondrial dysfunction. We will describe and discuss new insights on neuroendocrine-immuneéffects linked to allostatic load and its impact on the cellular and molecular responses; the links between allostatic load, inflammation, andéndothelial dysfunction; theépidemiologicalévidence supporting the pathophysiological origins of hypertension; and the biologicalémbedding of allostatic load and hypertension with anémphasis on mitochondrial dysfunction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALLOSTATIC LOAD
dc.subject
HYPERTENSION
dc.subject
INFLAMMATION
dc.subject
MITOCHONDRIAL DYSFUNCTION
dc.subject
PSYCHOSOCIAL STRESS
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Hypertension linked to allostatic load: From psychosocial stress to inflammation and mitochondrial dysfunction
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T16:46:17Z
dc.journal.volume
22
dc.journal.number
2
dc.journal.pagination
169-181
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Mocayar Maron, Feres Jose. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Ferder, Leon Fernando. University of Miami; Estados Unidos
dc.description.fil
Fil: Saraví, Fernando Daniel. University of Miami; Estados Unidos
dc.description.fil
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Stress
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/10253890.2018.1542683
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/10253890.2018.1542683
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