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dc.contributor.author
Ajayi, Ebenezer Idowu O
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Molehin, Olorunfemi R.
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Oloyede, Omotade I.
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Kumar, Vinodu
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Amara, Venkateswara R.
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Kaur, Jasmine
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Karpe, Pinakin
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Tikoo, Kulbhushan B.
dc.date.available
2020-12-23T20:59:42Z
dc.date.issued
2019-10-10
dc.identifier.citation
Ajayi, Ebenezer Idowu O; Molehin, Olorunfemi R.; Oloyede, Omotade I.; Kumar, Vinodu; Amara, Venkateswara R.; et al.; Liver mitochondrial membrane permeability modulation in insulin-resistant, uninephrectomised male rats by Clerodendrum volubile P. Beauv and Manihot esculenta Crantz; BioMed Central; Clinical Phytoscience; 5; 31; 10-10-2019; 1-9
dc.identifier.uri
http://hdl.handle.net/11336/121176
dc.description.abstract
Background: Non-alcoholic fatty liver disease, which occurs in people who are not alcohol drinkers, describes some of the pathogenic conditions that may be in the least characterized by simple steatosis or can be as serious as non-alcoholic steatohepatitis and cirrhosis. Its mechanistic pathogenesis has been said to arise from insulin resistance and oxidative stress, which may be compounded by obesity. An experimental model showing, systemic insulin resistance, obesity and accumulated hepatic fatty acids was created in adult male rats using high-fat diet manipulation and surgical removal of the left kidney (uninephrectomy). This study sought to identify the impact of these multiple burdens on the liver mitochondrial membrane permeability transition pore opening, and the possible in vitro effects of the extracts of Clerodendrum volubile and Manihot esculenta leaves on the membrane permeabilization. Results: The results indicated that the methanolic extract of Clerodendrum volubile leaf inhibited mitochondrial membrane pore opening in the insulin resistance condition or when it is followed by uni-nephrectomy, while the ethanolic extract of Manihot esculenta leaf does the same in the insulin resistance condition both prior to and following uni-nephrectomy. Conclusion: Since the vegetable extracts were able to abrogate mitochondrial pore opening at low concentrations, the structural integrity of the mitochondria can possibly be restored over time if treated by the vegetable extracts. Research efforts should, therefore, be made to harness the drugability of the bioactives of these vegetables for use in the treatment of non-alcoholic fatty liver disease arising from insulin resistance and renal failure.
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application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
INSULIN RESISTANCE
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UNINEPHRECTOMY
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NON-ALCOHOLIC FATTY LIVER DISEASE
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MITOCHONDRIA
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NATURAL PRODUCTS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Liver mitochondrial membrane permeability modulation in insulin-resistant, uninephrectomised male rats by Clerodendrum volubile P. Beauv and Manihot esculenta Crantz
dc.type
info:eu-repo/semantics/article
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info:ar-repo/semantics/artículo
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info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:17:44Z
dc.identifier.eissn
2199-1197
dc.journal.volume
5
dc.journal.number
31
dc.journal.pagination
1-9
dc.journal.pais
Suazilandia
dc.description.fil
Fil: Ajayi, Ebenezer Idowu O. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Osun State University; Nigeria. National Institute of Pharmaceutical Education and Research; India
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Fil: Molehin, Olorunfemi R.. Ekiti State University; Nigeria
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Fil: Oloyede, Omotade I.. Ekiti State University; Nigeria
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Fil: Kumar, Vinodu. National Institute of Pharmaceutical Education and Research; India
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Fil: Amara, Venkateswara R.. National Institute of Pharmaceutical Education and Research; India
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Fil: Kaur, Jasmine. National Institute of Pharmaceutical Education and Research; India
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Fil: Karpe, Pinakin. National Institute of Pharmaceutical Education and Research; India
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Fil: Tikoo, Kulbhushan B.. National Institute of Pharmaceutical Education and Research; India
dc.journal.title
Clinical Phytoscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://clinphytoscience.springeropen.com/articles/10.1186/s40816-019-0124-0
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s40816-019-0124-0
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