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dc.contributor.author
Galotto, Camila
dc.contributor.author
Cambiasso, Maite Yael
dc.contributor.author
Julianelli, Vanina Laura
dc.contributor.author
Rey Valzacchi, Gaston Javier
dc.contributor.author
Rolando, R. N.
dc.contributor.author
Rodriguez, M. L.
dc.contributor.author
Calvo, L.
dc.contributor.author
Calvo, Juan Carlos
dc.contributor.author
Romanato, Marina
dc.date.available
2020-12-22T20:21:08Z
dc.date.issued
2019-11-06
dc.identifier.citation
Galotto, Camila; Cambiasso, Maite Yael; Julianelli, Vanina Laura; Rey Valzacchi, Gaston Javier; Rolando, R. N.; et al.; Human sperm decondensation in vitro is related to cleavage rate and embryo quality in IVF; Springer/Plenum Publishers; Journal of Assisted Reproduction and Genetics; 36; 11; 6-11-2019; 2345-2355
dc.identifier.issn
1058-0468
dc.identifier.uri
http://hdl.handle.net/11336/121078
dc.description.abstract
Purpose: To investigate whether the ability of human spermatozoa to decondense in vitro in the presence of heparin (Hep) and glutathione (GSH) is related to assisted reproduction (ART) success. Methods: Cross-sectional pilot study involving male partners of 129 infertile couples undergoing ICSI with (45) or without (84) donor oocytes at two infertility clinics in CABA, Argentina, between October 2012 and December 2013. In vitro decondensation kinetics with Hep and GSH and DNA fragmentation (TUNEL) were determined on the same sample used for ICSI. The possible relationship of decondensation parameters (maximum decondensation and decondensation velocity) and TUNEL values with ART success was evaluated. Results: Embryo quality correlated positively with decondensation velocity (D60/D30) (Spearman?s correlation, p < 0.05). According to D60/D30 values, patients were classified as slow decondensers (SlowD) (n = 68) or fast decondensers (FastD) (n = 61). Embryo quality was better in FastD (unpaired t test, p < 0.05). FastD and SlowD were subdivided according to use of donor oocytes. Among SlowD, biochemical and clinical pregnancy rates per transfer were significantly higher in donor (n = 19) vs. in non-donor (n = 31) cycles (Fisher?s exact test, p < 0.05). TUNEL values were not related to embryo quality, but no clinical pregnancies or live births were achieved in TUNEL+ SlowD (n = 7). Conclusion: Decondensation kinetics of human spermatozoa in vitro with Hep and GSH could be related to embryo quality and ART success.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ART SUCCESS
dc.subject
DNA FRAGMENTATION
dc.subject
HEPARIN
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HUMAN SPERMATOZOA
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SPERM DECONDENSATION
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Human sperm decondensation in vitro is related to cleavage rate and embryo quality in IVF
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-17T18:31:05Z
dc.journal.volume
36
dc.journal.number
11
dc.journal.pagination
2345-2355
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Galotto, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Cambiasso, Maite Yael. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Julianelli, Vanina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Procrearte; Argentina
dc.description.fil
Fil: Rey Valzacchi, Gaston Javier. Procrearte; Argentina. Hospital Italiano; Argentina
dc.description.fil
Fil: Rolando, R. N.. Hospital Italiano; Argentina
dc.description.fil
Fil: Rodriguez, M. L.. Hospital Italiano; Argentina
dc.description.fil
Fil: Calvo, L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Romanato, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Journal of Assisted Reproduction and Genetics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10815-019-01590-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10815-019-01590-y
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