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dc.contributor.author
Lustig, Livia
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dc.contributor.author
Guazzone, Vanesa Anabella
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dc.contributor.author
Tung, Kenneth S. K.
dc.contributor.other
Rose, Noel
dc.contributor.other
Mackay, Ian
dc.date.available
2020-12-18T12:51:25Z
dc.date.issued
2019
dc.identifier.citation
Lustig, Livia; Guazzone, Vanesa Anabella; Tung, Kenneth S. K.; Autoimmune orchitis and autoimmune oophoritis; Academic Press Inc Elsevier Science; 2019; 1235-1246
dc.identifier.isbn
978-0-12-812102-3
dc.identifier.uri
http://hdl.handle.net/11336/120822
dc.description.abstract
Experimental studies predict a frequent occurrence of human gonadal autoimmunity. In spontaneous multi-organ models of autoimmune diseases, the testis and ovary are frequent targets. Although progress in clinical research has been slow, in part explained by the success of assisted reproduction techniques, experimental studies have yielded exceptional information on the fundamental mechanisms of tolerance and autoimmunity. They include the discovery and functional analysis of the CD4+ CD25+ Foxp3+ regulatory T cells (Treg) as a major tolerance mechanism, the sequel of autoimmune regulator (AIRE) gene deficiency, molecular mimicry as a basis of autoreactive T cell response, the epitope spreading phenomenon in autoantibody production, and neonatal propensity in autoimmunity development. In addition, they provide guidelines for translational research into human disease, and better understanding of chronic inflammatory conditions of the gonads associated with subfertility and infertility. Finally, knowledge of the local immune regulation in testis as an immune privilege site, and the recently discovered systemic tolerance mechanism, have contributed to a more complete understanding of the immunological control against gonadal autoantigens, as well as to the numerous human cancer antigens that they share with normal germ cell antigens in testes and ovaries (the cancer/testis antigens). In this chapter, we will present the experimental autoimmune models, followed by a description of existing data supporting an autoimmune basis in human testicular and ovarian diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TESTIS
dc.subject
OVARY
dc.subject
INFERTILITY
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Autoimmune orchitis and autoimmune oophoritis
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-11-18T17:27:10Z
dc.journal.pagination
1235-1246
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Lustig, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Guazzone, Vanesa Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Tung, Kenneth S. K.. No especifíca;
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/B9780128121023000622
dc.conicet.paginas
1532
dc.source.titulo
The Autoimmune Diseases
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