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dc.contributor.author
Funes, Samanta Celeste
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dc.contributor.author
de Lara, Amaranta Manrique
dc.contributor.author
Altamirano Lagos, María J.
dc.contributor.author
Mackern Oberti, Juan Pablo
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dc.contributor.author
Escobar Vera, Jorge
dc.contributor.author
Kalergis, Alexis M.
dc.date.available
2020-12-17T17:16:45Z
dc.date.issued
2019-04
dc.identifier.citation
Funes, Samanta Celeste; de Lara, Amaranta Manrique; Altamirano Lagos, María J.; Mackern Oberti, Juan Pablo; Escobar Vera, Jorge; et al.; Immune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy; Elsevier Science; Autoimmunity Reviews; 18; 4; 4-2019; 359-368
dc.identifier.issn
1568-9972
dc.identifier.uri
http://hdl.handle.net/11336/120787
dc.description.abstract
The immune system is responsible for defending the host from a large variety of potential pathogens, while simultaneously avoiding immune reactivity towards self-components. Self-tolerance has to be tightly maintained throughout several central and peripheral processes; immune checkpoints are imperative for regulating the immunity/tolerance balance. Dendritic cells (DCs) are specialized cells that capture antigens, and either activate or inhibit antigen-specific T cells. Therefore, they play a key role at inducing and maintaining immune tolerance. DCs that suppress the immune response have been called tolerogenic dendritic cells (tolDCs). Given their potential as a therapy to prevent transplant rejection and autoimmune damage, several strategies are under development to generate tolDCs, in order to avoid activation and expansion of self-reactive T cells. In this article, we summarize the current knowledge relative to the main features of tolDCs, their mechanisms of action and their therapeutic use for autoimmune diseases. Based on the literature reviewed, autologous antigen-specific tolDCs might constitute a promising strategy to suppress autoreactive T cells and reduce detrimental inflammatory processes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUTOIMMUNITY
dc.subject
IMMUNE CHECKPOINTS
dc.subject
IMMUNOTHERAPY
dc.subject
TOLERANCE
dc.subject
TOLEROGENIC DENDRITIC CELLS
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Immune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T16:46:20Z
dc.journal.volume
18
dc.journal.number
4
dc.journal.pagination
359-368
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Funes, Samanta Celeste. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: de Lara, Amaranta Manrique. Pontificia Universidad Católica de Chile; Chile. Universidad Nacional Autónoma de México; México
dc.description.fil
Fil: Altamirano Lagos, María J.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Escobar Vera, Jorge. Universidad de Antofagasta; Chile
dc.description.fil
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
dc.journal.title
Autoimmunity Reviews
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1568997219300321
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.autrev.2019.02.006
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