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dc.contributor.author
Penissi, Alicia Beatriz
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dc.contributor.other
Muzzalupo, Innocenzo
dc.date.available
2020-12-17T14:44:34Z
dc.date.issued
2019
dc.identifier.citation
Penissi, Alicia Beatriz; Regulation of immune and nonimmune mast cell activation by phenols from olive oil; IntechOpen; 2019; 1-15
dc.identifier.isbn
978-1-83962-645-6
dc.identifier.uri
http://hdl.handle.net/11336/120755
dc.description.abstract
The purpose of this study is to establish if hydroxytyrosol and oleuropein, themost significant phenols found in olive oil and olives, can inhibit the activation of mast cells induced by immune and nonimmune pathways. Preincubation of purified peritoneal mast cells was carried out in the presence of hydroxytyrosol or oleuropein compounds and, prior to incubation, with concanavalin A, compound 48/80, or calcium ionophore A23187. Dose-response and time-dependence were studied. Comparative studies were performed using sodium cromoglycate, a well-known mast cell stabilizer. The supernatants and pellets were analyzed for β-hexosaminidase content via colorimetric reaction after incubation. The percentage of β-hexosaminidase obtained in each tube was measured and taken as a referent mast cell activation indicator. Other cell pellet samples were studied for cell viability, by means of the trypan blue exclusion method, or analyzed with light and electron microscopy. For the first time, biochemical and morphological results have shown that hydroxytyrosol and oleuropein inhibit degranulation of mast cells triggered by both immune and nonimmune causes. These findings suggest that olive phenols, specifically hydroxytyrosol and oleuropein, may be set the bases for developing practical tools not only to prevent and treat mast cell-mediated disorders butalso to improve olive oil industrialization.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IntechOpen
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
β-HEXOSAMINIDASE
dc.subject
DEGRANULATION
dc.subject
HYDROXYTYROSOL
dc.subject
MAST CELL
dc.subject
OLEUROPEIN
dc.subject
OLIVE
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Regulation of immune and nonimmune mast cell activation by phenols from olive oil
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-11-20T16:39:52Z
dc.journal.pagination
1-15
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Penissi, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5772/intechopen.84595
dc.conicet.paginas
200
dc.source.titulo
Technological Innovation in the Olive Oil Production Chain
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