Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1

In different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolar stress alters the normal cellular development. The transient receptor potential vanilloid 1 (TRPV-1) is a non-selective cation channel that is activated by hyperosmolarity and participates in many cellular processes. TPRV-1 is expressed in human placenta at term. Here, we evaluated the expression of TRPV-1 in first trimester extravillous trophoblast cells and its participation in the survival of these cells exposed to hyperosmolar stress. Our results showed that hyperosmolar stress up-regulates the expression of TRPV-1 and induces the apoptosis in Swan 71 cells. In addition, the inhibition of TRPV-1 abrogates the apoptotic events.

Palabras clave: APOPTOSIS , EVT , HYPEROSMOLARITY , TRPV-1

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/120728

URL: https://www.sciencedirect.com/science/article/abs/pii/S0006291X19307338

DOI: http://dx.doi.org/10.1016/j.bbrc.2019.04.091

Colecciones

Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS

Articulos(IFIBIO HOUSSAY)
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY

Citación

Reppetti, Julieta; Etcheverry, Tomás; Sierra, Matías N.; Damiano, Alicia Ermelinda; Farina, Mariana; et al.; Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 514; 1; 6-2019; 58-63

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