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Artículo

Participation of 5-lipoxygenase and LTB4 in liver regeneration after partial hepatectomy

Lorenzetti, FlorenciaIcon ; Vera, Marina CeciliaIcon ; Ceballos Mancini, María PaulaIcon ; Ronco, Maria TeresaIcon ; Pisani, Gerardo Bruno; Monti, Juan Alberto; Lucci, AlvaroIcon ; Comanzo, Carla GabrielaIcon ; Tordjmann, Thierry; Carrillo, María Cristina; Quiroga, Ariel DarioIcon ; Alvarez, María de LujánIcon
Fecha de publicación: 12/2019
Editorial: Nature
Revista: Scientific Reports
e-ISSN: 2045-2322
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Médicas

Resumen

Regeneration is the unmatched liver ability for recovering its functional mass after tissue lost. Leukotrienes (LT) are a family of eicosanoids with the capacity of signaling to promote proliferation. We analyzed the impact of blocking LT synthesis during liver regeneration after partial hepatectomy (PH). Male Wistar rats were subjected to two-third PH and treated with zileuton, a specific inhibitor of 5-lipoxygenase (5-LOX). Our first find was a significant increment of intrahepatic LTB4 during the first hour after PH together with an increase in 5-LOX expression. Zileuton reduced hepatic LTB4 levels at the moment of hepatectomy and also inhibited the increase in hepatic LTB4. This inhibition produced a delay in liver proliferation as seen by decreased PCNA and cyclin D1 nuclear expression 24 h post-PH. Results also showed that hepatic LTB4 diminution by zileuton was associated with a decrease in NF-ĸB activity. Additionally, decreased hepatic LTB4 levels by zileuton affected the recruitment of neutrophils and macrophages. Non-parenchymal cells (NPCs) from zileuton-treated PH-rats displayed higher apoptosis than NPCs from PH control rats. In conclusion, the present work provides evidences that 5-LOX activation and its product LTB4 are involved in the initial signaling events for liver regeneration after PH and the pharmacological inhibition of this enzyme can delay the initial time course of the phenomenon.
Palabras clave: LEUKOTRIENES , LIVER REGENERATION , 5-LIPOXYGENASE , ZILEUTON
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/120647
URL: https://www.nature.com/articles/s41598-019-54652-7
DOI: https://doi.org/10.1038/s41598-019-54652-7
Colecciones
Articulos(IFISE)
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Citación
Lorenzetti, Florencia; Vera, Marina Cecilia; Ceballos Mancini, María Paula; Ronco, Maria Teresa; Pisani, Gerardo Bruno; et al.; Participation of 5-lipoxygenase and LTB4 in liver regeneration after partial hepatectomy; Nature; Scientific Reports; 9; 1; 12-2019; 1-14; 18176
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